Περίληψη:
Stromal cell derived factor-1 (SDF-1), a CXC chemokine that plays an
important role in the tumor growth, angiogenesis and metastasis of tumor
cells, has a polymorphism at position 801 of its 3’-untranslated region,
known as SDF1-3’A. The SDF1-3’A polymorphism has been investigated in
various types of cancer, but no information is currently available on
its role in pancreatic cancer. In this study, 80 pancreatic cancer
patients and 160 normal healthy control subjects were investigated for
the genotype and allelic frequencies of the SDF-1 gene using PCR-RFLP.
The genotype frequencies for GG, GA and AA were 21.25, 77.5 and 1.25%
in patients, and 42.5, 55 and 2.5% in healthy subjects, respectively.
The A carrier group (GA+AA genotype) and the A allele were
overrepresented among the patients with pancreatic cancer (p=0.015 and
p=0.031, respectively). The GA+AA genotype was statistically correlated
with an advanced T stage and the presence of lymph node metastasis, and
displayed a clear trend towards significance in relation to the presence
of distant metastatic disease (p=0.061). Only T stage was significantly
related to A allele frequency (p=0.004). SDF1-3’ A allele carriers were
more prevalent among cancer patients than among normal subjects. SDF1-3’
A allele carrier status may imply a higher risk of pancreatic cancer,
while the presence of the A allele in pancreatic cancer patients may be
related to aggressive features of this malignancy.
Συγγραφείς:
Theodoropoulos, George E.
Panoussopoulos, George S. and
Michalopoulos, Nikolaos V.
Zambirinis, Constantinos P.
Taka,
Stiliani
Stamopoulos, Paraskevas
Gazouli, Maria
Zografos, G.
