Τίτλος:
Age, beta thalassaemia trait, and iron-deficient anaemia significantly
affect reticulocyte indices in pre-school children
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Reticulocyte indices are easy to obtain, low cost parameters and have
gained interest in the field of diagnosing anaemias of childhood.
We assessed distribution, age and gender variation, relation to indices
of iron metabolism and diagnostic performance of reticulocyte
haemoglobin content (CHr), percentage of microcytic reticulocytes
(micro_r), percentage of hypochromic reticulocytes (hypo_r), and
percentage of reticulocytes with low CHr (low_CHr) in 386 pre-school
children classified in four groups: healthy, iron deficiency (ID), iron
deficiency anaemia (IDA), and beta-thalassaemia carriers (beta-thal).
Age had a positive effect in CHr (Spearman’s rho = 0.21) and a negative
effect in hypo_r (Spearman’s rho = -0.2) in healthy children. CHr and
low_CHr were related to ferritin in the IDA group (Spearman’s rho 0.55
and -0.53, respectively). In the beta-thal group, HbA(2) is strongly
related to all reticulocyte indices. micro_r and CHr performed best in
discriminating between IDA and beta-thal heterozygosity (ROC analysis,
area under the curve (AUC): 0.76 and 0.74, respectively). CHr achieved
the best AUC (0.58) in identifying ID among children without anaemia.
Age, IDA and beta-thal significantly affect reticulocyte indices. CHr
and micro_r may have a role as screening tools in discriminating
between IDA and beta-thal heterozygosity.
Συγγραφείς:
Chouliaras, Giorgos L.
Stamoulakatou, Alexandra
Tsiftis, George
and Perissaki, Georgia
Premetis, Evangelos
Lycopoulou, Lilia
Περιοδικό:
European Journal of Pediatrics
Λέξεις-κλειδιά:
Reticulocyte indices; Iron deficiency; Anaemia; ROC analysis; Reference
range; beta-thalassaemia heterozygosity
DOI:
10.1007/s00431-010-1186-7
