Τίτλος:
Survivin Expression in Colorectal Carcinomas: Correlations with
Clinicopathological Parameters and Survival
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Survivin is a new member of the Inhibitor of apoptosis
protein family that has a dual function as a mitotic regulator and
apoptosis inhibitor. Survivin is prominently expressed in transformed
cell lines and in many human cancers, including colorectal carcinoma.
The aim of this study is to investigate the expression of survivin in
colorectal carcinomas and its possible associations with
clinicopathological parameters and patient survival.
Materials and Methods Sections of formalin-fixed paraffin-embedded
tissues from 77 colorectal carcinomas were immunohistochemistry stained
for survivin.
Results Survivin was mainly detected in the bottom of the glands of
normal mucosa with mainly cytoplasmic localization. No survivin
expression was found in infiltrating lymphocytes, fibroblasts, smooth
muscle cells or neural tissue. Survivin staining was detected in 68/77
(88.3%) colorectal carcinomas. Survivin expression was found to be
significantly associated with tumor differentiation (P = 0.02) but not
with gender, age or Dukes stage. Survival did not differ according to
survivin expression.
Conclusion Survivin was found in the majority of colorectal carcinomas,
suggesting that its expression is an early event in colorectal
carcinogenesis. Its expression is statistically significantly associated
with tumor differentiation but not with patient survival.
Συγγραφείς:
Kalliakmanis, J. G.
Kouvidou, Ch.
Latoufis, C.
Kouvatseas,
G.
Anagnostakis, D.
Papatheodoridis, G.
Koskinas, J. and
Archimandritis, A.
Περιοδικό:
Digestive Diseases and Sciences
Λέξεις-κλειδιά:
Survivin; Colorectal carcinoma; Clinicopathological parameters; Survival
DOI:
10.1007/s10620-009-1088-6
