Περίληψη:
We conducted a multi-stage, genome-wide association study of bladder
cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals
(cases) and 5,120 controls of European descent from five studies
followed by a replication strategy, which included 8,382 cases and
48,275 controls from 16 studies. In a combined analysis, we identified
three new regions associated with bladder cancer on chromosomes 22q13.1,
19q12 and 2q37.1: rs1014971, (P = 8 x 10(-12)) maps to a non-genic
region of chromosome 22q13.1, rs8102137 (P = 2 x 10(-11)) on 19q12 maps
to CCNE1 and rs11892031 (P = 1 x 10(-7)) maps to the UGT1A cluster on
2q37.1. We confirmed four previously identified genome-wide associations
on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous
candidate associations for the GSTM1 deletion (P = 4 x 10(-11)) and a
tag SNP for NAT2 acetylation status (P = 4 x 10(-11)), and found
interactions with smoking in both regions. Our findings on common
variants associated with bladder cancer risk should provide new insights
into the mechanisms of carcinogenesis.
Συγγραφείς:
Rothman, Nathaniel
Garcia-Closas, Montserrat
Chatterjee,
Nilanjan
Malats, Nuria
Wu, Xifeng
Figueroa, Jonine D. and
Real, Francisco X.
Van den Berg, David
Matullo, Giuseppe and
Baris, Dalsu
Thun, Michael
Kiemeney, Lambertus A.
Vineis,
Paolo
De Vivo, Immaculata
Albanes, Demetrius
Purdue, Mark P.
and Rafnar, Thorunn
Hildebrandt, Michelle A. T.
Kiltie, Anne E.
and Cussenot, Olivier
Golka, Klaus
Kumar, Rajiv
Taylor, Jack
A.
Mayordomo, Jose I.
Jacobs, Kevin B.
Kogevinas, Manolis
and Hutchinson, Amy
Wang, Zhaoming
Fu, Yi-Ping and
Prokunina-Olsson, Ludmila
Burdett, Laurie
Yeager, Meredith and
Wheeler, William
Tardon, Adonina
Serra, Consol
Carrato,
Alfredo
Garcia-Closas, Reina
Lloreta, Josep
Johnson, Alison
and Schwenn, Molly
Karagas, Margaret R.
Schned, Alan and
Andriole, Jr., Gerald
Grubb, III, Robert
Black, Amanda and
Jacobs, Eric J.
Diver, W. Ryan
Gapstur, Susan M.
Weinstein,
Stephanie J.
Virtamo, Jarmo
Cortessis, Victoria K. and
Gago-Dominguez, Manuela
Pike, Malcolm C.
Stern, Mariana C. and
Yuan, Jian-Min
Hunter, David J.
McGrath, Monica
Dinney,
Colin P.
Czerniak, Bogdan
Chen, Meng
Yang, Hushan and
Vermeulen, Sita H.
Aben, Katja K.
Witjes, J. Alfred and
Makkinje, Remco R.
Sulem, Patrick
Besenbacher, Soren and
Stefansson, Kari
Riboli, Elio
Brennan, Paul
Panico,
Salvatore
Navarro, Carmen
Allen, Naomi E.
Bueno-de-Mesquita,
H. Bas
Trichopoulos, Dimitrios
Caporaso, Neil
Landi, Maria
Teresa
Canzian, Federico
Ljungberg, Borje
Tjonneland, Anne
and Clavel-Chapelon, Francoise
Bishop, David T.
Teo, Mark T. W.
and Knowles, Margaret A.
Guarrera, Simonetta
Polidoro, Silvia
and Ricceri, Fulvio
Sacerdote, Carlotta
Allione, Alessandra and
Cancel-Tassin, Geraldine
Selinski, Silvia
Hengstler, Jan G. and
Dietrich, Holger
Fletcher, Tony
Rudnai, Peter
Gurzau, Eugen
and Koppova, Kvetoslava
Bolick, Sophia C. E.
Godfrey, Ashley and
Xu, Zongli
Sanz-Velez, Jose I.
Garcia-Prats, Maria D. and
Sanchez, Manuel
Valdivia, Gabriel
Porru, Stefano
Benhamou,
Simone
Hoover, Robert N.
Fraumeni, Jr., Joseph F.
Silverman,
Debra T.
Chanock, Stephen J.
