Τίτλος:
Serological evidence of Mycoplasma pneumoniae infection in patients with
acute exacerbation of COPD: analysis of 100 hospitalizations
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: A prospective study was conducted in order to investigate the
serologic evidence of Mycoplasma pneumoniae infection in Greek
hospitalized patients with acute exacerbation of chronic obstructive
pulmonary disease (AECOPD). Furthermore, we have assessed the frequency
of a number of variables in the group of patients with a serological
diagnosis of an acute M. pneumoniae infection compared to patients in
whom M. pneumoniae infection was not documented.
Materials/Methods: One hundred patients with AECOPD were enrolled in a
29-month study period. Serum IgG, IgA and IgM M. pneumoniae antibody
titers were determined during the first day of their hospitalization and
30 days after enrolment, using a commercial ELISA.
Results: Nine patients (9%) had serological evidence of an acute M.
pneumoniae infection. Acute infection was mainly documented by IgA
antibody titer changes. It was mainly attributed to a reinfection rather
than a primary infection. Patients with serological evidence of an acute
M. pneumoniae infection had a higher heart rate (99+/-12 versus 88+/-14
beats/minute, p=0.02) and a higher hematocrit value (47+/-4.5% versus
40.4+/-6.2%, p=0.004) at admission than patients without a serological
diagnosis for this pathogen.
Conclusions: Serologic evidence of M. pneumoniae infection is rather
common in Greek hospitalized patients with AECOPD. The determination of
all three antibody classes was necessary in order to obtain an optimal
level of serodiagnosis. No differences were found in the majority of
characteristics of patients with and without serological evidence for
this pathogen. The clinical utility of these results should be further
clarified in future studies.
Συγγραφείς:
Papaetis, G. S.
Anastasakou, E.
Tselou, T.
Sotiriou, A. and
Rarra, V. C.
Roussou, P.
Karakatsani, A.
Orphanidou, D.
Περιοδικό:
Advances in Medical Sciences
Εκδότης:
Medical University of Bialystok
Λέξεις-κλειδιά:
Mycoplasma pneumoniae; COPD; exacerbation; ELISA
DOI:
10.2478/v10039-010-0031-6
