Περίληψη:
Many cytotoxic agents used in cancer treatment exert their effects
through their ability to directly or indirectly damage DNA and thus
resulting in cell death. Major types of DNA damage induced by anticancer
treatment include strand breaks (double or single strand), crosslinks
(inter-strand, intra-strand, DNA-protein crosslinks), and interference
with nucleotide metabolism and DNA synthesis. On the other hand, cancer
cells activate various DNA repair pathways and repair DNA damages
induced by cytotoxic drugs. The purpose of the current review is to
present the major types of DNA damage induced by cytotoxic agents, DNA
repair pathways, and their role as predictive agents, as well as
evaluate the future perspectives of the novel DNA repair pathways
inhibitors in cancer therapeutics.
