Τίτλος:
No association between educational level and pancreatic cancer incidence
in the European Prospective Investigation into Cancer and Nutrition
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: Until now, studies examining the relationship between
socioeconomic status and pancreatic cancer incidence have been
inconclusive. Aim: To prospectively investigate to what extent
pancreatic cancer incidence varies according to educational level within
the European Prospective Investigation into Cancer and Nutrition (EPIC)
study. Methods: In the EPIC study, socioeconomic status at baseline was
measured using the highest level of education attained. Hazard ratios by
educational level and a summary index, the relative indices of
inequality (Rh), were estimated using Cox regression models stratified
by age, gender, and center and adjusted for known risk factors. In
addition, we conducted separate analyses by age, gender and geographical
region. Results: Within the source population of 407, 944 individuals at
baseline, 490 first incident primary pancreatic adenocarcinoma cases
were identified in 9 European countries. The crude difference in risk of
pancreatic cancer according to level of education was small and not
statistically significant (RII = 1.14, 95% CI 0.80-1.62). Adjustment
for known risk factors reduced the inequality estimates to only a small
extent. In addition, no statistically significant associations were
observed for age groups (adjusted RII <= (60) (years) = 0.85, 95% CI
0.44-1.64, adjusted RII> 60 years = 1.18, 95% CI 0.73-1.90), gender
(adjusted RIImale = 1.20, 95% CI 0.68-2.10, adjusted RIIfemale = 0.96,
95% CI 0.56-1.62) or geographical region (adjusted RIINorthern Europe =
1.14, 95% CI 0.81-1.61, adjusted RIIMiddle (Europe) = 1.72, 95% CI
0.93-3.19, adjusted RIISouthern Europe = 0.75, 95% CI 0.32-1.80).
Conclusion: Despite large educational inequalities in many risk factors
within the EPIC study, we found no evidence for an association between
educational level and the risk of developing pancreatic cancer in this
European cohort. (C) 2010 Elsevier Ltd. All rights reserved.
Συγγραφείς:
van Boeckel, Petra G. A.
Boshuizen, Hendriek C.
Siersema, Peter
D.
Vrieling, Alina
Kunst, Anton E.
Ye, Weimin
Sund,
Malin
Michaud, Dominique S.
Gallo, Valentina
Spencer,
Elizabeth A.
Trichopoulou, Antonia
Benetou, Vasiliki and
Orfanos, Philippos
Cirera, Lluis
Duell, Eric J.
Rohrmann,
Sabine
Hemann, Silke
Masala, Giovanni
Manjer, Jonas and
Mattiello, Amalia
Lindkvist, Bjorn
Sanchez, Maria-Jose
Pala,
Valeria
Peeters, Petra H. M.
Braaten, Tonje
Tjonneland, Anne
and Dalton, Susanne Oksbjerg
Larranaga, Nerea
Dorronsoro, Miren
and Overvad, Kim
Illner, Anne-Kathrin
Ardanaz, Eva
Marron,
M.
Straif, K.
Riboli, E.
Bueno-de-Mesquita, B.
Περιοδικό:
Cancer Epidemiology and Prevention Biomarkers
Εκδότης:
Elsevier Sci Ltd, Exeter, United Kingdom
Λέξεις-κλειδιά:
Pancreatic cancer incidence; Epidemiology; Socioeconomic status;
Educational level
DOI:
10.1016/j.canep.2010.08.004
