Περίληψη:
The worldwide incidence of gastric adenocarcinoma (GC) is lower in women
than in men. Furthermore, cancer patients treated with estrogens have
been reported to have a lower subsequent risk of GC. The authors
conducted a prospective analysis of menstrual and reproductive factors,
exogenous hormone use, and GC in 335,216 women from the European
Prospective Investigation Into Cancer and Nutrition, a cohort study of
individuals aged 35-70 years from 10 European countries. After a mean
follow-up of 8.7 years (through 2004), 181 women for whom complete
exposure data were available developed GC. Adjusted hazard ratios and
95% confidence intervals were estimated using Cox proportional hazards
models. All statistical tests were 2-sided. Women who had ovariectomy
had a 79% increased risk of GC (based on 25 cases) compared with women
who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78).
Total cumulative years of menstrual cycling was inversely associated
with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95%
confidence interval: 0.31, 0.98; P(trend) = 0.06). No other reproductive
factors analyzed were associated with risk of GC. The results of this
analysis provide some support for the hypothesis that endogenous ovarian
sex hormones lower GC incidence in women.
Συγγραφείς:
Duell, Eric J.
Travier, Noemie
Lujan-Barroso, Leila and
Boutron-Ruault, M. C.
Clavel-Chapelon, F.
Palli, Domenico and
Krogh, Vittorio
Mattiello, Amalia
Tumino, Rosario
Sacerdote,
Carlotta
Rodriguez, Laudina
Sanchez-Cantalejo, Emilio and
Navarro, Carmen
Barricarte, Aurelio
Dorronsoro, Miren
Khaw,
Kay-Tee
Wareham, Nicholas
Allen, Naomi E.
Tsilidis,
Konstantinos K.
Bueno-de-Mesquita, H. Bas
Jeurnink, Suzanne M.
and Numans, M. E.
Peeters, Petra H. M.
Lagiou, Pagona and
Valanou, Elisabeth
Trichopoulou, Antonia
Kaaks, Rudolf and
Lukanova-McGregor, Annekatrin
Bergman, Manuela M.
Boeing, Heiner
and Manjer, Jonas
Lindkvist, Bjorn
Stenling, Roger
Hallmans,
Goran
Dahm, Christina C.
Overvad, Kim
Olsen, Anja and
Tjonneland, Anne
Bakken, Kjersti
Lund, Eiliv
Jenab, Mazda
and McCormack, Valerie
Rinaldi, Sabina
Michaud, Dominique and
Mouw, Traci
Nesi, Gabriella
Carneiro, Fatima
Riboli, Elio
and Gonzalez, Carlos A.
