Τίτλος:
Hypersensitivity Reactions to Docetaxel: Retrospective Evaluation and
Development of a Desensitization Protocol
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Docetaxel (DT) is an extensively used taxane, frequently
associated with hypersensitivity reactions. The aim of this study was to
record the epidemiological and clinical features of hypersensitivity to
DT in non-small cell lung cancer patients in order to obtain useful
information concerning the management of these patients. We also
developed a desensitization protocol and evaluated its clinical
application. Methods: We retrospectively reviewed records of 620
non-small cell lung cancer patients treated with DT-containing regimens
in the adjuvant, first-, second- or next-line setting. Data from 102
patients who had exhibited hypersensitivity reactions were analyzed
according to the Common Toxicity Criteria for Adverse Events version
3.0. Five patients were chosen for the desensitization protocol. We
applied the standard protocol for parenteral desensitization to
beta-lactam antibiotics, and DT treatment was carried out with a series
of 10-fold dilutions in sufficient volume to administer the total dose.
Results: One hundred and two patients (16.5%) were recorded as having
hypersensitivity to DT. Reactions were observed after approximately 2.5
+/- 1.0 cycles. Only 14 patients (14/620, 2%) developed grade 3-4
hypersensitivity. Reactions were more likely in patients during
second-or third-line chemotherapy, but no other correlation (age,
gender, atopic status) was observed. Five patients completed a
parenteral desensitization protocol and continued their treatment
uneventfully. Conclusions: Hypersensitivity reactions to DT respond
quickly to discontinuation along with appropriate supportive care.
Premedication and increased infusion time may allow readministration.
The desensitization protocol that we developed provides a reliable
alternative to permanent discontinuation of DT. Copyright (C) 2011 S.
Karger AG, Basel
Συγγραφείς:
Syrigou, Ekaterini
Dannos, Ioannis
Kotteas, Elias
Makrilia,
Nektaria
Tourkantonis, Ioannis
Dilana, Kalliopi
Gkiozos,
Ioannis
Saif, Muhammad Wasif
Syrigos, Kostas N.
Περιοδικό:
International Archives of Allergy and Immunology
Λέξεις-κλειδιά:
Desensitization; Docetaxel; Hypersensitivity reactions; Lung cancer
