Τίτλος:
Comparison of Fibrate, Ezetimibe, Low- and High-Dose Statin Therapy for
the Dyslipidemia of the Metabolic Syndrome in a Mouse Model
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and Aim: The treatment-of-choice for the optimal management
of the dyslipidemia of the metabolic syndrome (MetS) is not clearly
defined. We compared the efficacy of 4 drug regimes for the management
of this dyslipidemia in a mouse model. Materials and Methods: A total of
60 C57B16 mice comprised the study group. The first 10 received standard
mouse food for the whole experiment (control group). The remaining 50
mice received atherogenic diet for 14 weeks until the development of the
MetS. The mice were then divided into 5 groups: the 1st group continued
receiving atherogenic diet, while the other 4 groups received
atherogenic diet plus ezetimibe (10 mg/kg per day), fenofibrate (100
mg/kg per day), low-dose atorvastatin (10 mg/kg per day), or high-dose
(40 mg/kg per day) atorvastatin, respectively, for another 8 weeks.
Results: High-dose atorvastatin treatment achieved the best lipid
profile compared with low-dose atorvastatin, ezetimibe, and fibrate
therapy. The lipid profile of mice receiving atherogenic diet plus
high-dose atorvastatin treatment was similar with mice on regular chow.
Conclusions: High-dose atorvastatin treatment resulted in optimization
of the lipid profile in the presence of a high-fat atherogenic diet in a
mouse model. Our results suggest that high-dose atorvastatin treatment
may be the optimal treatment option for the dyslipidemia associated with
MetS. Nevertheless, verification of these results in humans is required
before any definite conclusions can be drawn.
Συγγραφείς:
Paraskevas, Kosmas I.
Pantopoulou, Alkistis
Vlachos, Ioannis S.
and Agrogiannis, George
Iliopoulos, Dimitrios G.
Karatzas,
Gabriel
Tzivras, Dimitrios
Mikhailidis, Dimitri P.
Perrea,
Despina N.
Περιοδικό:
International Angiology
Εκδότης:
SAGE Publications Inc.
Λέξεις-κλειδιά:
metabolic syndrome; statins; ezetimibe; fibrates; dyslipidemia
DOI:
10.1177/0003319710387919
