Τίτλος:
Exhaled NO and exhaled breath condensate pH in the evaluation of asthma
control
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Asthma is a chronic inflammatory airways disorder. However,
no biomarker of airways inflammation has been included in the assessment
of asthma control.
Objective: To evaluate exhaled NO (FeNO) and exhaled breath condensate
(EBC) pH in patients with asthma according to the level of control, and
their performance in the identification of not well-controlled patients.
Methods: FeNO and EBC pH after Argon deaeration were measured in 274
consecutive patients. Asthma control was evaluated by two asthma
specialists blinded to FeNO and pH measurements according to GINA
guidelines, as well as by asthma control test (ACT) and asthma control
questionnaire (ACQ).
Results: FeNO was higher and EBC pH was lower in patients with not
well-controlled compared to controlled asthma. In ROC analysis, FeNO
presented an AUC of 0.790 for the identification of not well-controlled
asthma performing better in non-smokers; EBC pH presented an AUC of
0.791 for the identification of not well-controlled asthma, performing
better in smokers. The performance of both biomarkers was inferior to
that of ACT and ACQ. FeNO values > 30 ppb presented positive predictive
values (PPV) > 0.85 with the exception of smokers treated with inhaled
corticosteroids. EBC pH values <= 7.20 presented PPV > 0.80 in all
groups. The presence of FeNO > 30 ppb and/or EBC pH <= 7.20 was
indicative of not well-uncontrolled asthma in 88.3% of the patients.
Conclusion: FeNO and EBC pH levels may identify patients with not
well-controlled asthma. However, their performance was inferior to
clinical judgment and may be limited to selected subgroups of asthmatic
patients. (c) 2010 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Kostikas, Konstantinos
Papaioannou, Andriana I.
Tanou, Kalliopi
and Giouleka, Paschalina
Koutsokera, Angela
Minas, Markos and
Papiris, Spyros
Gourgoulianis, Konstantinos I.
Taylor, D. Robin
and Loukides, Stelios
Περιοδικό:
Advances in Respiratory Medicine
Εκδότης:
W B SAUNDERS CO LTD
Λέξεις-κλειδιά:
Asthma control; Exhaled NO; Exhaled breath condensate pH; Inhaled
corticosteroids; Smoking
DOI:
10.1016/j.rmed.2010.10.015
