Τίτλος:
In Vitro Interactions of Antimicrobial Combinations with Fosfomycin
against KPC-2-Producing Klebsiella pneumoniae and Protection of
Resistance Development
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Using time-kill methodology, we investigated the interactions of
fosfomycin with meropenem or colistin or gentamicin against 17
genetically distinct Klebsiella pneumoniae clinical isolates carrying
bla(KPC-2). Synergy was observed with meropenem or colistin against 64.7
and 11.8% of tested isolates, while the combination with gentamicin
resulted in indifference. All studied combinations showed improved
bactericidal activity, compared to fosfomycin alone and prevented the
development of fosfomycin resistance in 69.2, 53.8, and 81.8% of
susceptible isolates, respectively.
Συγγραφείς:
Souli, Maria
Galani, Irene
Boukovalas, Stefanos
Gourgoulis,
Michael George
Chryssouli, Zoi
Kanellakopoulou, Kyriaki and
Panagea, Theofano
Giamarellou, Helen
Περιοδικό:
Antimicrobial Agents and Chemotherapy
Εκδότης:
AMER SOC MICROBIOLOGY
DOI:
10.1128/AAC.01086-10
