Περίληψη:
Objective: We investigated the association between the proportion of
long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma
phospholipids from blood samples drawn at enrollment and subsequent
change in body weight. Sex, age, and BMI were considered as potential
effect modifiers. Method: A total of 1,998 women and men participating
in the European Prospective Investigation into Cancer and Nutrition
(EPIC) were followed for a median of 4.9 years. The associations between
the proportion of plasma phospholipid long-chain n-3 PUFA and change in
weight were investigated using mixed-effect linear regression. Results:
The proportion of long-chain n-3 PUFA was not associated with change in
weight. Among all participants, the 1-year weight change was -0.7 g per
1% point higher long-chain n-3 PUFA level (95% confidence interval:
-20.7 to 19.3). The results when stratified by sex, age, or BMI groups
were not systematically different. Conclusion: The results of this study
suggest that the proportion of long-chain n-3 PUFA in plasma
phospholipids is not associated with subsequent change in body weight
within the range of exposure in the general population.
Συγγραφείς:
Jakobsen, Marianne U.
Dethlefsen, Claus
Due, Karen M. and
Slimani, Nadia
Chajes, Veronique
May, Anne M.
Sorensen,
Thorkild I. A.
Halkjaer, Jytte
Tjonneland, Anne and
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine and
Fagherazzi, Guy
Teucher, Birgit
Kaaks, Rudolf
Boeing, Heiner
and Schuetze, Madlen
Trichopoulou, Antonia
Zylis, Dimosthenis
and Makrygiannis, George
Palli, Domenico
Mattiello, Amalia and
Tagliabue, Giovanna
van der A, Daphne L.
Bueno-de-Mesquita, H.
B.
Rodriguez, Laudina
Travier, Noemie
Molina-Montes, Esther
and Huerta, Jose M.
Barricarte, Aurelio
Amiano, Pilar and
Manjer, Jonas
Wirfalt, Elisabet
Johansson, Ingegerd and
Hallmans, Goran
Khaw, Kay-Tee
Wareham, Nicholas J.
Crowe,
Francesca
Romieu, Isabelle
Riboli, Elio
Peeters, Petra H. M.
and Overvad, Kim
