Τίτλος:
IGF-I and IGFBP-3 before and after inpatient alcohol detoxification in
alcohol-dependent subjects
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: It is unclear whether alcohol detoxification has an effect
on factors that are involved in growth, metabolic functions and cell
proliferation. Alcohol abuse is associated with low IGF-I levels that
tend to rise after alcohol withdrawal. There is a paucity of studies on
the course of IGFBP-3 (the main binding protein for IGF-I) after alcohol
detoxification.
Material/Methods: We prospectively assessed IGF-I and IGFBP-3 changes at
the time of admission and after 4 to 6 weeks of detoxification in an
inpatient alcohol detoxification facility in 118 alcohol-dependent
subjects given a regular hospital diet. No participants dropped out of
the study.
Results: Changes in IGF-I after alcohol detoxification showed a marked
dimorphism in altered hepatic biochemistry upon admission, with a rise
in those with normal liver enzymes upon admission (p=0.016,
Kruskall-Wallis) and a drop in those with elevated liver enzymes upon
admission (p=0.05); the latter was noted in subjects that had consumed
alcohol close to the time of admission. Overall, however, IGF-I and
IGFBP-3 were within normal limits for most subjects both upon admission
and after alcohol detoxification; no significant differences were
detected among the examined parameters in men vs. women, and there were
no significant correlations of IGF-I, IGFBP-3 or the IGF-I/IGFBP-3 molar
ratio with BMI or age.
Conclusions: Regardless of hepatic enzymes’ elevation, alcohol
detoxification had overall slight effects on IGF-I and IGFBP-3.
Συγγραφείς:
Ilias, Ioannis
Paparrigopoulos, Thomas
Tzavellas, Elias and
Karaiskos, Dimitris
Kontoleon, Panagiotis
Liappas, Ioannis
Περιοδικό:
Medical science monitor basic research
Εκδότης:
International Scientific Information, Inc.
Λέξεις-κλειδιά:
alcohol; insulin-like growth factor type-1 (IGF-1); IGF-binding proteins
