Περίληψη:
Triple-negative breast cancers are an aggressive subtype of breast
cancer with poor survival, but there remains little known about the
etiologic factors that promote its initiation and development. Commonly
inherited breast cancer risk factors identified through genome-wide
association studies display heterogeneity of effect among breast cancer
subtypes as defined by the status of estrogen and progesterone
receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22
common breast cancer susceptibility variants were investigated in 2,980
Caucasian women with triple-negative breast cancer and 4,978 healthy
controls. We identified six single-nucleotide polymorphisms, including
rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737
(RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly
associated with the risk of triple-negative breast cancer. Together, our
results provide convincing evidence of genetic susceptibility for
triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.
Συγγραφείς:
Stevens, Kristen N.
Vachon, Celine M.
Lee, Adam M.
Slager,
Susan
Lesnick, Timothy
Olswold, Curtis
Fasching, Peter A.
and Miron, Penelope
Eccles, Diana
Carpenter, Jane E.
Godwin,
Andrew K.
Ambrosone, Christine
Winqvist, Robert
Brauch,
Hiltrud
Schmidt, Marjanka K.
Cox, Angela
Cross, Simon S. and
Sawyer, Elinor
Hartmann, Arndt
Beckmann, Matthias W. and
Schulz-Wendtland, Ruediger
Ekici, Arif B.
Tapper, William J. and
Gerty, Susan M.
Durcan, Lorraine
Graham, Nikki
Hein, Rebecca
and Nickels, Stephan
Flesch-Janys, Dieter
Heinz, Judith and
Sinn, Hans-Peter
Konstantopoulou, Irene
Fostira, Florentia and
Pectasides, Dimitrios
Dimopoulos, Athanasios M.
Fountzilas,
George
Clarke, Christine L.
Balleine, Rosemary
Olson, Janet
E.
Fredericksen, Zachary
Diasio, Robert B.
Pathak, Harsh and
Ross, Eric
Weaver, JoEllen
Ruediger, Thomas
Forsti, Asta and
Duennebier, Thomas
Ademuyiwa, Foluso
Kulkarni, Swati and
Pylkaes, Katri
Jukkola-Vuorinen, Arja
Ko, Yon-Dschun
Van
Limbergen, Erik
Janssen, Hilde
Peto, Julian
Fletcher, Olivia
and Giles, Graham G.
Baglietto, Laura
Verhoef, Senno and
Tomlinson, Ian
Kosma, Veli-Matti
Beesley, Jonathan
Greco,
Dario
Blomqvist, Carl
Irwanto, Astrid
Liu, Jianjun and
Blows, Fiona M.
Dawson, Sarah-Jane
Margolin, Sara
Mannermaa,
Arto
Martin, Nicholas G.
Montgomery, Grant W.
Lambrechts,
Diether
Silva, Isabel dos Santos
Severi, Gianluca
Hamann,
Ute
Pharoah, Paul
Easton, Douglas F.
Chang-Claude, Jenny and
Yannoukakos, Drakoulis
Nevanlinna, Heli
Wang, Xianshu
Couch,
Fergus J.
GENICA Consortium
