Περίληψη:
Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor
suppression, cell cycle arrest, repair of damaged DNA, detoxification of
reactive oxygen species, apoptosis and plays a pivotal role in promoting
longevity. FOXO3 is a key downstream target of the PI3K-Akt pathway in
response to cellular stimulation by growth factors or insulin and has
been proposed as a bridge between ageing and tumor suppression. Three
SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that have
been shown to be strongly and consistently associated with longevity,
were examined in relation to PC risk in a case control study of 1571
incident PC cases and 1840 controls nested within the European
Prospective Investigation into Cancer and Nutrition (EPIC). There was no
statistically significant association between the SNPs and PC risk
regardless of the model of inheritance (dominant, codominant and
recessive). The associations were not modified by disease
aggressiveness, circulating levels of steroid sex hormones, or IGFs or
BMI. We conclude that polymorphisms in the FOXO3 gene that are
associated with longevity are not major risk factors for PC risk, in
this population of Caucasian men.
Συγγραφείς:
Campa, Daniele
Huesing, Anika
Dostal, Lucie
Stein, Angelika
and Drogan, Dagmar
Boeing, Heiner
Tjonneland, Anne
Roswall,
Nina
Ostergaard, Jane Nautrup
Overvad, Kim
Rodriguez,
Laudina
Bonet, Catalina
Sanchez, Maria-Jose
Larranaga, Nerea
and Maria Huerta, Jose
Ardanaz, Eva
Khaw, Kay-Tee
Wareham,
Nicholas
Travis, Ruth C.
Allen, Naomi E.
Trichopoulou,
Antonia
Zylis, Dimosthenis
Karapetyan, Tina
Palli, Domenico
and Sieri, Sabina
Tumino, Rosario
Vineis, Paolo and
Bueno-De-Mesquita, H. Bas
Lenner, Per
Johansson, Mattias and
Jenab, Mazda
Cox, David
Siddiq, Afshan
Kaaks, Rudolf and
Canzian, Federico
