Περίληψη:
Background: Case-control studies suggest that patients with allergic
diseases have a lower risk of developing glioma but not meningioma or
schwannoma. However, those data can be differentially biased.
Prospective studies with objective measurements of immunologic
biomarkers, like immunoglobulin E (IgE), in blood obtained before cancer
diagnosis could help to clarify whether an aetiological association
exists.
Methods: The present case-control study nested within the European
Prospective Investigation into Cancer and Nutrition (EPIC) measured
specific serum IgE as a biomarker for the most common inhalant allergens
in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched
controls using the ImmunoCAP specific IgE test. Subjects with an IgE
level >= 0.35 kUA/l (kilo antibody units per litre) were classified as
sensitized by allergens. Odds ratios (OR) and 95% confidence intervals
(CI) were estimated by adjusted conditional logistic regression models
for each tumour subtype. The effect of dose-response relationship was
assessed in five increasing IgE level categories to estimate P-values
for trend.
Results: The risk of glioma was inversely related to allergic
sensitization (OR = 0.73; 95% CI 0.51-1.06), especially pronounced in
women (OR = 0.53; 95% CI 0.30-0.95). In dose-response analyses, for
high-grade glioma, the lowest OR was observed in sera with the highest
IgE levels (P for trend = 0.04). No association was seen for meningioma
and schwannoma.
Conclusion: The results, based on serum samples prospectively collected
in a cohort study, provide some support for the hypothesis that
individuals with allergic sensitization are at reduced risk of glioma
and confirm results from previous case-control studies.
Συγγραφείς:
Schlehofer, B.
Siegmund, B.
Linseisen, J.
Schuez, J. and
Rohrmann, S.
Becker, S.
Michaud, D.
Melin, B. and
Bueno-de-Mesquita, H. Bas
Peeters, P. H. M.
Vineis, P. and
Tjonneland, A.
Olsen, A.
Overvad, K.
Romieu, I.
Boeing,
H.
Aleksandrova, K.
Trichopoulou, A.
Bamia, C.
Lagiou,
P.
Sacerdote, C.
Palli, D.
Panico, S.
Sieri, S. and
Tumino, R.
Sanchez, M. -J.
Rodriguez, L.
Dorronsoro, M. and
Duell, E. J.
Chirlaque, M. -D.
Barricarte, A.
Borgquist, S.
and Manjer, J.
Gallo, V.
Allen, N. E.
Key, T. J.
Riboli,
E.
Kaaks, R.
Wahrendorf, J.
