Περίληψη:
Metabolic syndrome (MetS) is purportedly related to risk of developing
colorectal cancer; however, the association of MetS, as defined
according to recent international criteria, and colorectal cancer has
not been yet evaluated. In particular, it remains unclear to what extent
the MetS components individually account for such an association. We
addressed these issues in a nested case-control study that included
1,093 incident cases matched (1: 1) to controls by using incidence
density sampling. Conditional logistic regression was used to estimate
relative risks (RR) and 95% CIs. MetS was defined according to the
criteria of the National Cholesterol Education Program/Adult Treatment
Panel III (NCEP/ATPIII), the International Diabetes Federation (IDF),
and the 2009 harmonized definition. Among individual components,
abdominal obesity (RR = 1.51; 95% CI: 1.16-1.96) was associated with
colon cancer, whereas abnormal glucose metabolism was associated with
both colon (RR = 2.05; 95% CI: 1.57-2.68) and rectal cancer (RR = 2.07;
95% CI: 1.45-2.96). MetS, as defined by each of the definitions, was
similarly associated with colon cancer (e. g., RR = 1.91; 95% CI:
1.47-2.42 for MetS by NCEP/ATPIII), whereas MetS by NCEP/ATPIII, but not
IDF or harmonized definition, was associated with rectal cancer (RR =
1.45; 95% CI: 1.02-2.06). Overall, these associations were stronger in
women than in men. However, the association between MetS and colorectal
cancer was accounted for by abdominal obesity and abnormal glucose
metabolism such that MetS did not provide risk information beyond these
components (likelihood ratio test P = 0.10 for MetS by NCEP/ATPIII).
These data suggest that simple assessment of abnormal glucose metabolism
and/or abdominal obesity to identify individuals at colorectal cancer
risk may have higher clinical utility than applying more complex MetS
definitions. Cancer Prev Res; 4(11); 1873-83. (C) 2011 AACR.
Συγγραφείς:
Aleksandrova, Krasimira
Boeing, Heiner
Jenab, Mazda and
Bueno-de-Mesquita, H. Bas
Jansen, Eugene
van Duijnhoven, Franzel
J. B.
Fedirko, Veronika
Rinaldi, Sabina
Romieu, Isabelle and
Riboli, Elio
Romaguera, Dora
Overvad, Kim
Ostergaard, Jane
Nautrup
Olsen, Anja
Tjonneland, Anne
Boutron-Ruault,
Marie-Christine
Clavel-Chapelon, Francoise
Morois, Sophie and
Masala, Giovanna
Agnoli, Claudia
Panico, Salvatore
Tumino,
Rosario
Vineis, Paolo
Kaaks, Rudolf
Lukanova, Annekatrin and
Trichopoulou, Antonia
Naska, Androniki
Bamia, Christina and
Peeters, Petra H.
Rodriguez, Laudina
Buckland, Genevieve and
Sanchez, Maria-Jose
Dorronsoro, Miren
Huerta, Jose-Maria and
Barricarte, Aurelio
Hallmans, Goran
Palmqvist, Richard
Khaw,
Kay-Tee
Wareham, Nicholas
Allen, Naomi E.
Tsilidis,
Konstantinos K.
Pischon, Tobias
