Τίτλος:
Oxytocin and Psychological Factors Affecting Type 2 Diabetes Mellitus
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background. The aim of this study was to investigate the association of
oxytocin with trait and state psychological factors in type 2 diabetic
patients. Methods. OXT and psychological variables were analyzed from 86
controlled diabetic patients (glycosylated haemoglobin A1c (HbA1c) <
7%) from 45 uncontrolled diabetic patients (HbA1c >= 7). Psychological
characteristics were assessed with the Eysenck Personality Questionnaire
(EPQ), while state psychological characteristics were measured with the
Symptom Checklist 90-R (SCL 90-R). Blood samples were taken for
measuring oxytocin in both subgroups during the initial phase of the
study. One year later, the uncontrolled diabetic patients were
reevaluated with the use of the same psychometric instruments. Results.
During the first evaluation of the uncontrolled diabetic patients, a
statistically significant positive relationship between the levels of
OXT and psychoticism in EPQ rating scale (P < 0.013) was observed. For
controlled diabetic patients, a statistically significant negative
relationship between oxytocin and somatization (P < 0.030), as well as
obsessive-compulsive scores (P < 0.047) in SCL-90 rating scale, was
observed. During the second assessment, the values of OXT decreased when
the patients managed to control their metabolic profile. Conclusions.
The OXT is in association with psychoticism, somatization, and
obsessionality may be implicated in T2DM.
Συγγραφείς:
Kontoangelos, K.
Raptis, A. E.
Papageorgiou, C. C.
Tsiotra,
P. C.
Papadimitriou, G. N.
Rabavilas, A. D.
Dimitriadis, G.
and Raptis, S. A.
Περιοδικό:
Experimental Diabetes Research
