Τίτλος:
Conflicting effects of nitric oxide and oxidative stress in chronic
heart failure: potential therapeutic strategies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Chronic heart failure (CHF) is characterized by decreased nitric oxide
(NO) bioavailability. In addition, the beneficial NO turns to be
deleterious when it reacts with superoxide anion, leading to
peroxynitrite formation. Numerous experimental and clinical studies have
reported increased production of reactive oxygen species (superoxide,
hydrogen peroxide, hydroxyl radical) both in animals and patients with
CHF. Moreover, there are indicative data suggesting mechanisms
associated with endothelial dysfunction in states of CHF, mainly
attributed to decreased NO bioavailability and enhanced inactivation of
the latter. Thus, such molecules appear to be potential targets in
patients with CHF. These patients are strong candidates to receive a
variety of therapeutic agents, some of which have known antioxidant
effects. Classic treatment with statins or angiotensin converting enzyme
inhibitors has been found to be beneficial in restoring NO and improving
myocardial function and structure. Other agents such as sildenafil and
b-blockers along with novel agents such as NO synthase transcription
enhancers have been proved to be also beneficial, but their use for such
a purpose is still controversial. Approaches using more-effective
antioxidants or targeting myocardial oxidant-producing enzymes and
oxidative or nitrosative stress might be promising strategies in the
future.
Συγγραφείς:
Tousoulis, Dimitris
Papageorgiou, Nikolaos
Briasoulis,
Alexandros
Androulakis, Emmanouel
Charakida, Marietta and
Tsiamis, Eleftherios
Stefanadis, Christodoulos
Περιοδικό:
Heart Failure Reviews
Λέξεις-κλειδιά:
Heart failure; Nitric oxide; Oxidative stress; Peroxynitrite
DOI:
10.1007/s10741-011-9228-4
