Περίληψη:
Primary gastric lymphoma is a rare cancer of the stomach with an
indeterminate prognosis. Recently, a series of molecular prognostic
markers has been introduced to better describe this clinical entity.
This review describes the clinical importance of several oncogenes,
apoptotic genes and chromosomal mutations in the initiation and progress
of primary non-Hodgkin gastric lymphoma and their effect on patient
survival. We also outline the prognostic clinical importance of certain
cellular adhesion molecules, such as ICAM and PECAM-1, in patients with
gastric lymphoma, and we analyze the correlation of these molecules with
apoptosis, angiogenesis, tumour growth and metastatic potential. We also
focus on the host-immune response and the impact of Helicobacter pylori
infection on gastric lymphoma development and progression. Finally, we
explore the therapeutic methods currently available for gastric
lymphoma, comparing the traditional invasive approach with more recent
conservative options, and we stress the importance of the application of
novel molecular markers in clinical practice.
Συγγραφείς:
Alevizos, Leonidas
Gomatos, Ilias P.
Smparounis, Spyridon and
Konstadoulakis, Manousos M.
Zografos, Georgios
