Περίληψη:
Background: The study aimed to investigate the role of medical history
(skin warts, Candida albicans, herpetic lesions, heartburn,
regurgitation) and medication use (for heartburn; for regurgitation;
aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.
Methods: A multicentre (10 European countries) case-control study
[Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project].
Results: There were 1779 cases of UADT cancer and 1993 controls. History
of warts or C. albicans infection was associated with a reduced risk
[odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR
0.73, 95% CI 0.60-0.89, respectively] but there was no association with
herpetic lesions, heartburn, regurgitation or medication for related
symptoms. Regurgitation was associated with an increased risk for cancer
of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was
not associated with risk of UADT cancer overall but was associated with
a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96),
hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI
0.54-1.01).
Conclusions: A history of some infections appears to be a marker for
decreased risk of UADT cancer. The role of medical history and
medication use varied by UADT subsites with aspirin use associated with
a decreased risk of oesophageal cancer and suggestive of a decreased
risk of hypopharyngeal and laryngeal cancers.
Συγγραφείς:
Macfarlane, T. V.
Macfarlane, G. J.
Thakker, N. S.
Benhamou,
S.
Bouchardy, C.
Ahrens, W.
Pohlabeln, H.
Lagiou, P. and
Lagiou, A.
Castellsague, X.
Agudo, A.
Slamova, A.
Plzak,
J.
Merletti, F.
Richiardi, L.
Talamini, R.
Barzan, L.
and Kjaerheim, K.
Canova, C.
Simonato, L.
Conway, D. I. and
McKinney, P. A.
Thomson, P.
Sloan, P.
Znaor, A.
Healy,
C. M.
McCartan, B. E.
Marron, M.
Brennan, P.
