Περίληψη:
Oxidative stress has been shown to play an important role in
carcinogenesis, but prospective evidence for an association between
biomarkers of oxidative stress and colorectal cancer (CRC) risk is
limited. The authors investigated the association between prediagnostic
serum levels of oxidative stress indicators (i.e., reactive oxygen
metabolites (ROM) and ferric reducing ability of plasma (FRAP)) and CRC
risk. This was examined in a nested case-control study (1,064 CRC cases,
1,064 matched controls) in the European Prospective Investigation Into
Cancer and Nutrition cohort (1992-2003). Incidence rate ratios and 95%
confidence intervals were calculated using conditional logistic
regression analyses. ROM were associated with overall CRC risk (highest
tertile vs. lowest: adjusted incidence rate ratio (IRRadj) = 1.91, 95%
confidence interval (CI): 1.47, 2.48), proximal (IRRadj = 1.89, 95% CI:
1.06, 3.36) and distal (IRRadj = 2.31, 95% CI: 1.37, 3.89) colon
cancer, and rectal cancer (IRRadj = 1.69, 95% CI: 1.05, 2.72). When
results were stratified by tertile of follow-up time, the association
remained significant only in participants with less than 2.63 years of
follow-up (IRRadj = 2.28, 95% CI: 1.78, 2.94; P-heterogeneity < 0.01).
FRAP was not associated with CRC risk. In conclusion, prediagnostic
serum ROM levels were associated with increased risk of CRC. However,
this association was seen only in subjects with relatively short
follow-up, suggesting that the association results from production of
reactive oxygen species by preclinical tumors.
Συγγραφείς:
Leufkens, Anke M.
van Duijnhoven, Franzel J. B.
Woudt, Sjoukje
H. S.
Siersema, Peter D.
Jenab, Mazda
Jansen, Eugene H. J.
M.
Pischon, Tobias
Tjonneland, Anne
Olsen, Anja
Overvad,
Kim
Boutron-Ruault, Marie Christine
Clavel-Chapelon, Francoise
and Morois, Sophie
Palli, Domenico
Pala, Valeria
Tumino,
Rosario
Vineis, Paolo
Panico, Salvatore
Kaaks, Rudolf and
Lukanova, Annekatrin
Boeing, Heiner
Aleksandrova, Krasimira and
Trichopoulou, Antonia
Trichopouios, Dimitrios
Dilis, Vardis and
Peeters, Petra H.
Skeie, Guri
Gonzalez, Carlos A. and
Argueelles, Marcial
Sanchez, Maria-Jose
Dorronsoro, Miren and
Huerta, Jose Maria
Ardanaz, Eva
Hallmans, Goran
Palmqvist,
Richard
Khaw, Kay-Tee
Wareham, Nick
Allen, Naomi E. and
Crowe, Francesca L.
Fedirko, Veronika
Norat, Teresa
Riboli,
Elio
Bueno-de-Mesquita, H. Bas
