Περίληψη:
Background: Only about half the studies that have collected information
on the relevance of women’s height and body mass index to their risk of
developing ovarian cancer have published their results, and findings are
inconsistent. Here, we bring together the worldwide evidence, published
and unpublished, and describe these relationships.
Methods and Findings: Individual data on 25,157 women with ovarian
cancer and 81,311 women without ovarian cancer from 47 epidemiological
studies were collected, checked, and analysed centrally. Adjusted
relative risks of ovarian cancer were calculated, by height and by body
mass index. Ovarian cancer risk increased significantly with height and
with body mass index, except in studies using hospital controls. For
other study designs, the relative risk of ovarian cancer per 5 cm
increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09;
p<0.001); this relationship did not vary significantly by women’s age,
year of birth, education, age at menarche, parity, menopausal status,
smoking, alcohol consumption, having had a hysterectomy, having first
degree relatives with ovarian or breast cancer, use of oral
contraceptives, or use of menopausal hormone therapy. For body mass
index, there was significant heterogeneity (p<0.001) in the findings
between ever-users and never-users of menopausal hormone therapy, but
not by the 11 other factors listed above. The relative risk for ovarian
cancer per 5 kg/m(2) increase in body mass index was 1.10 (95% CI,
1.07-1.13; p<0.001) in never-users and 0.95 (95% CI, 0.92-0.99; p =
0.02) in ever-users of hormone therapy.
Conclusions: Ovarian cancer is associated with height and, among
never-users of hormone therapy, with body mass index. In high-income
countries, both height and body mass index have been increasing in birth
cohorts now developing the disease. If all other relevant factors had
remained constant, then these increases in height and weight would be
associated with a 3% increase in ovarian cancer incidence per decade.
Συγγραφείς:
Beral, V.
Hermon, C.
Peto, R.
Reeves, G.
Brinton, L. and
Marchbanks, P.
Negri, E.
Ness, R.
Peeters, P. H. M. and
Vessey, M.
Calle, E. E.
Gapstur, S. M.
Patel, A. V.
Dal
Maso, L.
Talamini, R.
Chetrit, A.
Hirsh-Yechezkel, G. and
Lubin, F.
Sadetzki, S.
Allen, N.
Bull, D.
Callaghan, K.
and Crossley, B.
Gaitskell, K.
Goodill, A.
Green, J. and
Key, T.
Moser, K.
Collins, R.
Doll, R.
Gonzalez, C. A.
and Lee, N.
Ory, H. W.
Peterson, H. B.
Wingo, P. A. and
Martin, N.
Pardthaisong, T.
Silpisornkosol, S.
Theetranont,
C.
Boosiri, B.
Chutivongse, S.
Jimakorn, P.
Virutamasen,
P.
Wongsrichanalai, C.
Tjonneland, A.
Titus-Ernstoff, L. and
Byers, T.
Rohan, T.
Mosgaard, B. J.
Yeates, D. and
Freudenheim, J. L.
Chang-Claude, J.
Kaaks, R.
Anderson, K.
E.
Folsom, A.
Robien, K.
Rossing, M. A.
Thomas, D. B.
and Weiss, N. S.
Riboli, E.
Clavel-Chapelon, F.
Cramer, D.
and Hankinson, S. E.
Tworoger, S. S.
Franceschi, S.
La
Vecchia, C.
Magnusson, C.
Riman, T.
Weiderpass, E.
Wolk,
A.
Schouten, L. J.
van den Brandt, P. A.
Chantarakul, N. and
Koetsawang, S.
Rachawat, D.
Palli, D.
Black, A.
de
Gonzalez, A. Berrington
Freedman, D. M.
Hartge, P.
Hsing, A.
W.
Lacey, Jr., J. V.
Hoover, R. N.
Schairer, C. and
Graff-Iversen, S.
Selmer, R.
Bain, C. J.
Green, A. C. and
Purdie, D. M.
Siskind, V.
Webb, P. M.
McCann, S. E. and
Hannaford, P.
Kay, C.
Binns, C. W.
Lee, A. H.
Zhang, M.
and Ness, R. B.
Nasca, P.
Coogan, P. F.
Palmer, J. R. and
Rosenberg, L.
Kelsey, J.
Paffenbarger, R.
Whittemore, A. and
Katsouyanni, K.
Trichopoulou, A.
Trichopoulos, D.
Tzonou, A.
and Dabancens, A.
Martinez, L.
Molina, R.
Salas, O. and
Goodman, M. T.
Lurie, G.
Carney, M. E.
Wilkens, L. R. and
Hartman, L.
Manjer, J.
Olsson, H.
Grisso, J. A.
Morgan,
M.
Wheeler, J. E.
Casagrande, J.
Pike, M. C.
Ross, R. K.
and Wu, A. H.
Miller, A. B.
Kumle, M.
Lund, E.
McGowan,
L.
Shu, X. O.
Zheng, W.
Farley, T. M. M.
Holck, S. and
Meirik, O.
Risch, H. A.
Collaborative Grp Epidemiol Studie
