Τίτλος:
Tomato paste supplementation improves endothelial dynamics and reduces
plasma total oxidative status in healthy subjects
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Consumption of tomato products is linked to beneficial outcomes through
antioxidant and anti-inflammatory mechanisms. The aim of this study was
to determine whether a 14-day period of tomato paste supplementation
would improve endothelial function. Nineteen volunteers (mean age, 39
+/- 13 years; 8 men/11 women) were studied in a randomized (exposure
sequence), single-blind (operator), crossover design. The study
consisted of a supplementation arm (70 g tomato paste containing 33.3 mg
of lycopene) and a control arm, during which no tomato paste was added
to their regular diet. Volunteers maintained their regular diet during
study arms. Two-week washout periods preceded each arm. Flow-mediated
dilatation (FMD) measured by brachial artery ultrasonography was used as
an estimate of endothelial function at day 1 (acute response) and day 15
(midterm response). Plasma lipid peroxides were measured with a
photometric enzyme-linked immunosorbent assay as an index of total
oxidative status. Tomato supplementation led to an overall FMD increase
compared with the control period (P = .047 for repeated-measures 3 x 2
analysis of variance). At day 1, FMD was not significantly increased (P
= .329). By day 15, tomato supplementation resulted in an increase in
FMD by 3.3% +/- 1.4%, whereas at the control arm, FMD declined by
-0.5% +/- 0.6% (P = .03); magnitudes of change are absolute FMD
values. Total oxidative status decreased at the end of the
supplementation period compared with baseline values (P = .038). Daily
tomato paste consumption exerts a beneficial midterm but not short-term
effect on endothelial function. Further studies are warranted to explore
the effects of tomato paste on endothelial dilation in different age
groups and comorbidities. (C) 2012 Elsevier Inc. All rights reserved.
Συγγραφείς:
Xaplanteris, Panagiotis
Vlachopoulos, Charalambos
Pietri,
Panagiota
Terentes-Printzios, Dimitrios
Kardara, Despina and
Alexopoulos, Nikolaos
Aznaouridis, Konstantinos
Miliou, Antigoni
and Stefanadis, Christodoulos
Περιοδικό:
Nutrition Research
Εκδότης:
PERGAMON-ELSEVIER SCIENCE LTD
Λέξεις-κλειδιά:
Endothelial function; Lycopene; Carotenoids; Tomato; Antioxidant;
Crossover studies
DOI:
10.1016/j.nutres.2012.03.011
