Τίτλος:
Modest reversal of metabolic syndrome manifestations with vitamin D
status correction: a 12-month prospective study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Numerous cross-sectional studies have noted significant negative
associations between circulating levels of 25-hydroxyvitamin D and
cardiometabolic risk factors, highlighting potential extraskeletal
functions of this sterol hormone. Prospective studies, however, have
been limited; and hence, no cause-and-effect relations can be inferred.
This study aims to determine whether vitamin D status correction can
reverse already established manifestations of the metabolic syndrome
(MetS). A total of 59 adult nondiabetic, overweight, and obese Saudis
(31 male, 28 female) were prospectively enrolled in this 1-year
interventional study. Anthropometry and biochemical evaluation were
performed, including determination of serum 25-hydroxyvitamin D,
calcium, and phosphorous concentrations, as well as fasting blood
glucose and lipid profile. Subjects were advised to regularly expose
themselves to sunlight and increase intake of vitamin D-rich foods. All
measurements were repeated 6 and 12 months later. At the initial
baseline visit, the prevalence of both low high-density lipoprotein
cholesterol and hypertension was significantly increased among patients
with 25-vitamin D deficiency (P < .05), even after adjusting for sex and
body mass index. Overall prevalence of MetS patients by the modified
National Health and Nutrition Examination Survey Adult Treatment Panel
III definition decreased from 25.2% to 13.0%; and this was largely due
to a parallel decrease in the prevalence of low high-density lipoprotein
cholesterol, triglycerides, and hypertension. Optimization of vitamin D
status through sun exposure and increased intake of a vitamin D-rich
diet can lead to an improved cardiometabolic profile, offering a
promising nonpharmacologic approach in the prevention of MetS
manifestations. (C) 2012 Elsevier Inc. All rights reserved.
Συγγραφείς:
Al-Daghri, Nasser M.
Alkharfy, Khalid M.
Al-Saleh, Yousef and
Al-Attas, Omar S.
Alokail, Majed S.
Al-Othman, Abdulaziz and
Moharram, Osama
El-Kholie, Emad
Sabico, Shaun
Kumar, Sudhesh
and Chrousos, George P.
Περιοδικό:
Metabolism: Clinical and Experimental
Εκδότης:
W B SAUNDERS CO-ELSEVIER INC
DOI:
10.1016/j.metabol.2011.09.017
