Τίτλος:
Serum Hepcidin and Ferritin to Iron Ratio in Evaluation of Bacterial
Versus Viral Infections in Children A Single-center Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Differential diagnosis of childhood infections is important.
Several biochemical indices steer diagnosis toward bacterial agents,
although the data are often not definitive. Hepcidin is a central
component of blood iron, and ferritin alterations occur during
infections. We measured hepcidin changes and evaluated ferritin to iron
ratio (FIR) in patients with suspected infections.
Methods: We studied 69 children with infection and an equal number of
matched controls during a 3-year period. A bacterial agent was
demonstrated in 17 and a viral pathogen in 52 of the patients.
Hematologic and biochemical tests were performed on all children
including ferritin, iron and hepcidin. FIR was calculated and receiver
operating characteristic curve analysis was performed to evaluate the
best FIR cutoff value to discriminate between patients and controls and
between patients with bacterial infections and viral infections.
Results: Hepcidin, ferritin and FIR were significantly higher and iron
values significantly lower in febrile patients than its controls.
Patients with bacterial infection had significantly lower iron and
higher FIR than those with viral infection. FIR had high accuracy
discriminating patients from controls but only moderate accuracy
discriminating bacterial from viral infected patients.
Conclusions: If further studies with larger samples confirm these
observations, FIR could be used as an inexpensive, rapid and easily
performed complementary index for diagnosis of bacterial infections.
Συγγραφείς:
Kossiva, Lydia
Gourgiotis, Dimitrios I.
Tsentidis, Charalampos
and Anastasiou, Theodora
Marmarinos, Antonis
Vasilenko, Helen
and Sdogou, Triantafyllia
Georgouli, Helen
Περιοδικό:
The Pediatric Infectious Disease Journal
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
hepcidin; iron; ferritin; infection
DOI:
10.1097/INF.0b013e318256f843
