Τίτλος:
Influence of fetal glutathione S-transferase copy number variants on
adverse reproductive outcomes
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Please cite this paper as: Bustamante M, Danileviciute A, Espinosa A,
Gonzalez JR, Subirana I, Cordier S, Chevrier C, Chatzi L, Grazuleviciene
R, Sunyer J, Ibarluzea J, Ballester F, Villanueva CM, Nieuwenhuijsen M,
Estivill X, Kogevinas M. Influence of fetal glutathione S-transferase
copy number variants on adverse reproductive outcomes. BJOG
2012;119:11411146. A nested casecontrol association study was designed
to investigate the influence of maternal and fetal copy number variants
(CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST
and CYP genes were assessed. Significant associations were only found
for child CNV genotypes. In particular, the child GSTM1 insertion allele
was associated with prematurity protection (odds ratio, 95% CI: 0.67,
0.510.89; P < 0.01), whereas the child GSTT2B insertion allele was
associated with an increased risk of being small for gestational age
(odds ratio, 95% CI: 1.33, 1.071.67; P = 0.01). The study highlights
the role of the fetal genome in prenatal development and also the need
to analyse CNVs in a systematic manner.
Συγγραφείς:
Bustamante, M.
Danileviciute, A.
Espinosa, A.
Gonzalez, J.
R.
Subirana, I.
Cordier, S.
Chevrier, C.
Chatzi, L. and
Grazuleviciene, R.
Sunyer, J.
Ibarluzea, J.
Ballester, F.
and Villanueva, C. M.
Nieuwenhuijsen, M.
Estivill, X. and
Kogevinas, M.
Περιοδικό:
BJOG: An International Journal of Obstetrics and Gynaecology
Λέξεις-κλειδιά:
Copy number variant; glutathione S-transferase; preterm; small for
gestational age
DOI:
10.1111/j.1471-0528.2012.03400.x
