Τίτλος:
Inflammatory infiltration of metaplastic epithelium and correlation to
previous diagnosis of esophagitis and Barrett's length
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective. The contact of the gastric refluxate with the lower esophagus
results in an inflammatory-mediated tissue damage. The role of
inflammation both in the development and in the advance of Barrett’s
esophagus (BE) has not been elucidated. The aim of this study was to
assess the inflammatory infiltration in metaplastic Barrett’s epithelium
and to explore the association of microscopic inflammation to healed
esophagitis and Barrett’s length. Material and methods. Inflammatory
infiltration was qualitatively evaluated in well-characterized Barrett’s
specimens. Esophagitis was healed prior to histological sampling.
Univariate comparative analysis was performed based on BE length.
Results. Ninety-eight patients (78 male, mean age 58.3 +/- 13.3 yrs)
were retrospectively studied. Thirty-three cases with long segment BE
(LSBE) (33.7%) were spotted. Inflammatory infiltration was mild,
moderate, and severe in 35 (35.7%), 54 (55.1%), and 9 (9.1%)
specimens, respectively. The samples with moderate/severe inflammatory
infiltration were obtained from patients who had more frequently been
diagnosed with esophagitis (p = 0.025). Hiatal hernia (p = 0.001),
esophagitis (p = 0.019), and previous use of antisecretory drugs (p =
0.005) were more common in LSBE. Conclusions. Inflammatory infiltration
of Barrett’s epithelium was largely moderate despite preceding healing
of erosions with PPIs. Previous diagnosis of esophagitis correlated to
the degree of inflammation. No association of inflammation to Barrett’s
length was established.
Συγγραφείς:
Zampeli, Evanthia
Karamanolis, George
Morfopoulos, George and
Xirouchakis, Elias
Kalampoki, Vasiliki
Bamias, Giorgos and
Michopoulos, Spyros
Savva, Sotiria
Tzias, Vasilios and
Zouboulis-Vafiadis, Irene
Kamberoglou, Dimitrios
Ladas, Spiros
D.
Περιοδικό:
Scandinavian Journal of Gastroenterology
Εκδότης:
TAYLOR & FRANCIS LTD LONDON
Λέξεις-κλειδιά:
Barrett’s esophagus; esophagitis; inflammatory infiltration; long
Barrett; short Barrett
DOI:
10.3109/00365521.2012.688214
