Τίτλος:
Insulin Resistant Phenotype of Polycystic Ovary Syndrome does not Seem
to be Caused by Variation in FTO
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Genetic variation in the FTO gene is associated with increased body
weight and reduced insulin sensitivity. We investigated whether genetic
variation in FTO is associated with polycystic ovary syndrome (PCOS), a
condition also characterized by insulin resistance. Furthermore, we
tested whether insulin resistance is specifically associated with
genetic variation in FTO in women with PCOS. Sixty-two nondiabetic
patients with PCOS defined by the Rotterdam criteria were compared to
BMI and age-matched women. Each PCOS case was matched to 2 controls. All
participants underwent an oral glucose tolerance test and were genotyped
for the single nucleotide polymorphism rs8050136 in the FTO gene. There
was no difference in the frequency of FTO genotypes between the PCOS and
the non-PCOS groups. In non-PCOS participants, genetic variation in FTO
is associated with insulin sensitivity (p = 0.03). This association
remained significant after adjustment for age and/or BMI (p < = 0.03).
In subjects with PCOS, however, FTO did not associate with insulin
sensitivity (p = 0.67). Genetic variation in FTO does not have an impact
on insulin sensitivity in women with PCOS and is therefore not involved
in the pathogenesis of the insulin resistant phenotype seen in patients
with PCOS.
Συγγραφείς:
Hatziagelaki, E.
Wagner, R.
Kantartzis, K.
Heni, M. and
Linder, K.
Ketterer, C.
Machicao, F.
Stefan, N.
Staiger,
H.
Haering, H. U.
Fritsche, A.
Περιοδικό:
Hormone and Metabolic Research
Εκδότης:
Georg Thieme Verlag KG
Λέξεις-κλειδιά:
FTO; polycystic ovary syndrome (PCOS); insulin resistance; matched
case-control study
DOI:
10.1055/s-0032-1321817
