Περίληψη:
Several studies support a protective effect of dietary magnesium against
type 2 diabetes, but a harmful effect for iron. As diabetes has been
linked to pancreatic cancer, intake of these nutrients may be also
associated with this cancer. We examined the association between dietary
intake of magnesium, total iron and heme-iron and pancreatic cancer risk
in the European Prospective Investigation into Cancer and Nutrition
(EPIC) cohort. In total, 142,203 men and 334,999 women, recruited
between 1992 and 2000, were included. After an average follow-up of 11.3
years, 396 men and 469 women developed exocrine pancreatic cancer.
Hazard ratios and 95% confidence intervals (CIs) were obtained using
Cox regression stratified by age and center, and adjusted for energy
intake, smoking status, height, weight, and self-reported diabetes
status. Neither intake of magnesium, total iron nor heme-iron was
associated with pancreatic cancer risk. In stratified analyses, a
borderline inverse association was observed among overweight men (body
mass index, =25 kg/m2) with magnesium (HRper 100 mg/day increase = 0.79,
95% CI = 0.631.01) although this was less apparent using calibrated
intake. In female smokers, a higher intake of heme-iron was associated
with a higher pancreatic cancer risk (HR per 1 mg/day increase = 1.38,
95% CI = 1.101.74). After calibration, this risk increased
significantly to 2.5-fold (95% CI = 1.225.28). Overall, dietary
magnesium, total iron and heme-iron were not associated with pancreatic
cancer risk during the follow-up period. Our observation that heme-iron
was associated with increased pancreatic cancer risk in female smokers
warrants replication in additional study populations.
Συγγραφείς:
Molina-Montes, Esther
Wark, Petra A.
Sanchez, Maria-Jose and
Norat, Teresa
Jakszyn, Paula
Lujan-Barroso, Leila
Michaud,
Dominique S.
Crowe, Francesca
Allen, Naomi
Khaw, Kay-Tee and
Wareham, Nicholas
Trichopoulou, Antonia
Adarakis, George and
Katarachia, Helen
Skeie, Guri
Henningsen, Maria
Broderstad,
Ann Ragnhild
Berrino, Franco
Tumino, Rosario
Palli, Domenico
and Mattiello, Amalia
Vineis, Paolo
Amiano, Pilar and
Barricarte, Aurelio
Huerta, Jose-Maria
Duell, Eric J. and
Quiros, Jose-Ramon
Ye, Weimin
Sund, Malin
Lindkvist, Bjorn
and Johansen, Dorthe
Overvad, Kim
Tjonneland, Anne
Roswall,
Nina
Li, Kuanrong
Grote, Verena A.
Steffen, Annika and
Boeing, Heiner
Racine, Antoine
Boutron-Ruault, Marie-Christine
and Carbonnel, Franck
Peeters, Petra H. M.
Siersema, Peter D.
and Fedirko, Veronika
Jenab, Mazda
Riboli, Elio and
Bueno-de-Mesquita, Bas
