Τίτλος:
Correlation between mesenteric fat thickness and serum apolipoproteins
in patients with peripheral arterial occlusive disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Visceral fat possesses the most detrimental potential for
cardiovascular morbidity through the release of adipokines, as well as
metabolic and proinflammatory mediators, which adversely affect
metabolic and vascular homeostasis. Among the different types of
visceral adipose tissue, mesenteric fat is considered particularly
detrimental, due to its close proximity to the portal circulation,
affecting directly the liver, which is the main regulator of body
metabolic homeostasis. Mesenteric fat can be reliably estimated using
abdominal ultrasonography, the only available imaging method able to
depict individual mesenteric leaves. Aim of the present study was to
investigate the correlation of mesenteric fat thickness (MFT) with serum
apolipoprotein levels in patients undergoing digital subtraction
angiography in a single center.
Methods: 35 male patients with peripheral arterial disease were
examined. After careful examination of the periumbilical area, the
mesenteric leaves were identified. The maximal distance between each
pair of sequential leaves was measured, and the mean value of the three
thickest leaves was determined as the mesenteric fat thickness. Six
apolipoprotein fasting serum concentrations were measured using a
Luminex proteomics platform (xMAP Multiplex immunoassay): apolipoprotein
A-I (apoAI), apolipoprotein A-II (apoAII), apolipoprotein B (apoB),
apolipoprotein C-II (apoCII), apolipoprotein C-III (apoCIII) and
apolipoprotein E (apoE).
Results: MFT correlated with apoAII and apoB serum concentrations. The
correlations with apoAII and apoB remained significant following
correction for BMI. No correlations were noted between MFT and serum
apoAI, apoCII, apoCIII or apoE levels before or after adjustment for
BMI.
Conclusions: Our study indicates that MFT is significantly correlated
with the concentration of atherogenic low density lipoproteins
particles, as well as with apoAII, a determinant of free fatty acids
levels. No correlation was observed between mesenteric fat thickness and
very low density lipoprotein or chylomicron particles concentration.
Συγγραφείς:
Perelas, Apostolos
Safarika, Vanessa
Vlachos, Ioannis S. and
Tzanetakou, Irene
Korou, Laskarina-Maria
Konstantopoulos,
Panagiotis
Doulamis, Ilias
Ioannidis, Ioannis
Kornezos,
Ioannis
Gargas, Dimitrios
Klonaris, Christos
Perrea, Despina
N.
Chatziioannou, Achilleas
Περιοδικό:
Lipids in Health and Disease
Λέξεις-κλειδιά:
Ultrasound; Mesenteric fat thickness; Adipose tissue; Apolipoproteins;
Atherosclerosis
DOI:
10.1186/1476-511X-11-125
