Περίληψη:
Adiponectin an adipose tissue-derived protein may provide a molecular
link between obesity and colorectal cancer (CRC), but evidence from
large prospective studies is limited. In particular, no epidemiological
study explored high-molecular weight (HMW) and non-HMW adiponectin
fractions in relation to CRC risk, despite them being hypothesized to
have differential biological activities, i.e. regulating insulin
sensitivity (HMW adiponectin) versus inflammatory response (non-HNW
adiponectin). In a prospective, nested case control study, we
investigated whether prediagnostic serum concentrations of total, HMW
and non-HMW adiponectin are associated with risk of CRC, independent of
obesity and other known CRC risk factors. A total of 1206 incident cases
(755 colon and 451 rectal) were matched to 1206 controls using
incidence-density sampling. In conditional logistic regression, adjusted
for dietary and lifestyle factors, total adiponectin and non-HMW
adiponectin concentrations were inversely associated with risk of CRC
[relative risk (RR) comparing highest versus lowest quintile = 0.71,
95% confidence interval (CI) = 0.53-0.95, P-trend = 0.03 for total
adiponectin and RR = 0.45, 95% Cl = 0.34-0.61, P-trend < 0.0001 for
non-HMW adiponectin] HMW adiponectin concentrations were not associated
with CRC risk (RR = 0.91, 95% Cl = 0.68-1.22, P-trend = 0.55). Non-HMW
adiponectin was associated with CRC risk even after adjustment for body
mass index and waist circumference (RR = 0.39, 95% CI = 0.26-0.60,
P-trend < 0.0001), whereas the association with total adiponectin was no
longer significant (RR = 0.81, 95% CI = 0.60A.09, P-trend = 0.23). When
stratified by cancer site, non-HMW adiponectin was inversely associated
with both colon and rectal cancer. These findings suggest an important
role of the relative proportion of non-HMW adiponectin in CRC
pathogenesis. Future studies are warranted to confirm these results and
to elucidate the underlying mechanisms.
Συγγραφείς:
Aleksandrova, Krasimira
Boeing, Heiner
Jenab, Mazda and
Bueno-de-Mesquita, H. Bas
Jansen, Eugene
van Duijnhoven, Franzel
J. B.
Fedirko, Veronika
Rinaldi, Sabina
Romieu, Isabelle and
Riboli, Elio
Romaguera, Dora
Westphal, Sabine
Overvad, Kim
and Tjonneland, Anne
Boutron-Ruault, Marie Christine and
Clavel-Chapelon, Francoise
Kaaks, Rudolf
Lukanova, Annekatrin
and Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos, Dimitrios
and Agnoli, Claudia
Mattiello, Amalia
Saieva, Calogero and
Vineis, Paolo
Tumino, Rosario
Peeters, Petra H.
Argueelles,
Marcial
Bonet, Catalina
Sanchez, Maria-Jose
Dorronsoro,
Miren
Huerta, Jose-Maria
Barricarte, Aurelio
Palmqvist,
Richard
Hallmans, Goran
Khaw, Kay-Tee
Wareham, Nick and
Allen, Naomi E.
Crowe, Francesca L.
Pischon, Tobias
