Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3154390 76 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Menarche, menopause, and breast cancer risk: individual participant
meta-analysis, including 118 964 women with breast cancer from 117
epidemiological studies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Menarche and menopause mark the onset and cessation,
respectively, of ovarian activity associated with reproduction, and
affect breast cancer risk. Our aim was to assess the strengths of their
effects and determine whether they depend on characteristics of the
tumours or the affected women.
Methods Individual data from 117 epidemiological studies, including 118
964 women with invasive breast cancer and 306 091 without the disease,
none of whom had used menopausal hormone therapy, were included in the
analyses. We calculated adjusted relative risks (RRs) associated with
menarche and menopause for breast cancer overall, and by tumour
histology and by oestrogen receptor expression.
Findings Breast cancer risk increased by a factor of 1.050 (95% CI
1.044-1.057; p < 0.0001) for every year younger at menarche, and
independently by a smaller amount (1.029, 1.025-1.032; p < 0.0001), for
every year older at menopause. Premenopausal women had a greater risk of
breast cancer than postmenopausal women of an identical age (RR at age
45-54 years 1.43, 1.33-1.52, p < 0.001). All three of these associations
were attenuated by increasing adiposity among postmenopausal women, but
did not vary materially by women’s year of birth, ethnic origin,
childbearing history, smoking, alcohol consumption, or hormonal
contraceptive use. All three associations were stronger for lobular than
for ductal tumours (p < 0.006 for each comparison). The effect of
menopause in women of an identical age and trends by age at menopause
were stronger for oestrogen receptor-positive disease than for oestrogen
receptor-negative disease (p < 0.01 for both comparisons).
Interpretation The effects of menarche and menopause on breast cancer
risk might not be acting merely by lengthening women’s total number of
reproductive years. Endogenous ovarian hormones are more relevant for
oestrogen receptor-positive disease than for oestrogen receptor-negative
disease and for lobular than for ductal tumours.
Funding Cancer Research UK.
Έτος δημοσίευσης:
2012
Συγγραφείς:
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Bull, D.
Pirie, K.
Reeves, G.
Peto, R. and
Skegg, D.
LaVecchia, C.
Magnusson, C.
Pike, M. C. and
Thomas, D.
Hamajima, N.
Hirose, K.
Tajima, K.
Rohan, T.
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Gapstur, S. M.
Patel,
A. V.
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Talamini, R. and
Chantarakul, N.
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Rachawat, D.
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Stewart, W.
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Coogan, P. F.
Palmer, J. R. and
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Band, P.
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Canfell, K. and
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Horn-Ross, P. L.
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Kolonel, L. M.
Nomura, A. M. Y.
Ghiasvand, R.
Hu,
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Johnson, K. C.
Mao, Y.
Callaghan, K.
Crossley, B. and
Goodill, A.
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Lindgard, I.
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Anderson, G.
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Peeters,
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Trichopoulou, A.
Trichopoulos, D.
and Tzonou, A.
Baltzell, K. A.
Dabancens, A.
Martinez, L.
and Molina, R.
Salas, O.
Alexander, F. E.
Anderson, K. and
Folsom, A. R.
Gammon, M. D.
Hulka, B. S.
Millikan, R. and
Chilvers, C. E. D.
Lumachi, F.
Bain, C.
Schofield, F. and
Siskind, V.
Rebbeck, T. R.
Bernstein, L. R.
Enger, S. and
Haile, R. W.
Paganini-Hill, A.
Ross, R. K.
Ursin, G.
Wu,
A. H.
Yu, M. C.
Ewertz, Denmark M.
Clarke, E. A. and
Bergkvist, L.
Gass, M.
O'Sullivan, M. J.
Kalache, A. and
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Holck, S.
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Collaborative Grp Hormonal Factors
Collaborative Grp Hormonal
Factors
S Hankinson Nurses Hlth Study I II
Περιοδικό:
The lancet oncology
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Τόμος:
13
Αριθμός / τεύχος:
11
Σελίδες:
1141-1151
Επίσημο URL (Εκδότης):
DOI:
10.1016/S1470-2045(12)70425-4
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