Τίτλος:
Anogenital distance and the risk of prostate cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
OBJECTIVES
To measure anogenital distance in patients with prostate cancer and
control subjects without cancer.
To evaluate the association of anogenital distance with prostate cancer
in a case-control study in Spain.
MATERIALS AND METHODS
Anogenital distances from anus to upper penis (AGD(AP)) and from anus to
scrotum (AGD(AS)) were measured in 60 patients with prostate cancer in
two hospitals in Barcelona and in 52 urological controls.
Each measurement was performed three times by the same trained examiner
using a digital caliper
RESULTS
Patients had an approximate to 5 mm shorter AGD(AP) than controls,
whereas no difference was observed for AGD(AS).
A higher AGD(AP) was associated with a lower risk of prostate cancer,
with an adjusted odds ratio per 5 mm increase in AGD(AP) of 0.83 (95%
confidence interval, 0.70-0.99, P = 0.03).
CONCLUSIONS
The present study is the first to report anogenital measurements in
adults in relation to the risk of cancer.
The present study showed that a phenotype reflecting normal in utero
sexual development in men is associated with a lower risk of prostate
cancer.
There are two published studies (Mendiola et al. Environ Health Perspect
2011; 119 : 958-63; Eisenberg et al. PLoS One 2011; 6 : e18973)
evaluating sperm quality and fatherhood suggesting a connecting
mechanism related to the disruption of androgen-mediated pathways in
utero that affects reproductive potential and the risk of prostate
cancer.
Συγγραφείς:
Castano-Vinyals, Gemma
Carrasco, Estela
Antonio Lorente, Jose
and Sabate, Yasmin
Cirac-Claveras, Judith
Pollan, Marina and
Kogevinas, Manolis
Περιοδικό:
BJU international (Papier)
Λέξεις-κλειδιά:
anogenital distance; case-control study; prostate cancer
DOI:
10.1111/j.1464-410X.2012.11516.x
