Περίληψη:
Background: Evidence from prospective studies on intake of meat and fish
and risk of squamous cell carcinoma (SCC) of the upper aero-digestive
tract (UADT) is scarce. We prospectively investigated the association of
meat and fish intake with risk of SCC of the UADT and the possible
mechanism via heme iron in the large multicenter European Prospective
Investigation into Cancer and Nutrition (EPIC) study.
Methods: Multivariable proportional hazards models were used to estimate
relative risks (RR) of SCC of the UADT in relation to intake of total
meat, as well as subtypes of meat, fish, and heme iron among 348,738
individuals from 7 European countries.
Results: During an average follow-up of 11.8 years, a total of 682
incident cases of UADT SCC were accrued. Intake of processed meat was
positively associated with risk of SCC of the UADT in the total cohort
(highest vs. lowest quintile: RR = 1.41; 95% confidence interval (CI) =
1.03-1.941, however, in stratified analyses, this association was
confined to the group of current smokers (highest vs. lowest quintile:
RR = 1.89; 95% CI = 1.22-2.93). Red meat, poultry, fish, and heme iron
were not consistently related to UADT SCC.
Conclusion: Higher intake of processed meat was positively associated
with KC of the UADT among smokers. Although this finding was stable in
various sensitivity analyses, we cannot rule out residual confounding by
smoking. Confirmation in future studies and identification of biologic
mechanisms is warranted.
Impact: Smokers may further increase their risk for SCC of the UADT if
they additionally consume large amounts of processed meat. Cancer
Epidemiol Biomarkers Prev; 21(12); 2738-48. (C)2012 AACR.
Συγγραφείς:
Steffen, Annika
Bergmann, Manuela M.
Sanchez, Maria-Jose and
Chirlaque, Maria-Dolores
Jakszyn, Paula
Amiano, Pilar
Ramon
Quiros, J.
Barricarte Gurrea, Aurelio
Ferrari, Pietro and
Romieu, Isabelle
Fedirko, Veronika
Bueno-de-Mesquita, H. B(as)
and Siersema, Peter D.
Peeters, Petra H. M.
Khaw, Kay-Tee and
Wareham, Nick
Allen, Naomi E.
Crowe, Francesca L.
Skeie,
Guri
Hallmanns, Goran
Johansson, Ingegerd
Borgquist, Signe
and Ericson, Ulrika
Egeberg, Rikke
Tjonneland, Anne
Overvad,
Kim
Grote, Verena
Li, Kuanrong
Trichopoulou, Antonia and
Oikonomidou, Despoina
Pantzalis, Menelaos
Tumino, Rosario and
Panico, Salvatore
Palli, Domenico
Krogh, Vittorio
Naccarati,
Alessio
Mouw, Traci
Vergnaud, Anne-Claire
Norat, Teresa and
Boeing, Heiner
