Τίτλος:
Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide
from Maternal Diet: The European Prospective Mother-Child Study
(NewGeneris)
Περίληψη:
BACKGROUND: Acrylamide is a common dietary exposure that crosses the
human placenta. It is classified as a probable human carcinogen, and
developmental toxicity has been observed in rodents.
OBJECTIVES: We examined the associations between prenatal exposure to
acrylamide and birth outcomes in a prospective European mother child
study.
METHODS: Hemoglobin (Hb) adducts of acrylamide and its metabolite
glycidamide were measured in cord blood (reflecting cumulated exposure
in the last months of pregnancy) from 1,101 singleton pregnant women
recruited in Denmark, England, Greece, Norway, and Spain during
2006-2010. Maternal diet was estimated through food-frequency
questionnaires.
RESULTS: Both acrylamide and glycidamide Hb adducts were associated with
a statistically significant reduction in birth weight and head
circumference. The estimated difference in birth weight for infants in
the highest versus lowest quartile of acrylamide Hb adduct levels after
adjusting for gestational age and country was -132 g (95% CI: -207,
-56); the corresponding difference for head circumference was -0.33 cm
(95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers,
were consistent across countries, and remained after adjustment for
Factors associated with reduced birth weight. Maternal consumption of
foods rich in acrylamide, such as fried potatoes, was associated with
cord blood acrylamide adduct levels and with reduced birth weight.
CONCLUSIONS: Dietary exposure to acrylamide was associated with reduced
birth weight and head circumference. Consumption of specific foods
during pregnancy was associated with higher acrylamide exposure in
utero. IF confirmed, these findings suggest that dietary intake of
acrylamide should be reduced among pregnant women.
Συγγραφείς:
Pedersen, Marie
von Stedingk, Hans
Botsivali, Maria and
Agramunt, Silvia
Alexander, Jan
Brunborg, Gunnar
Chatzi,
Leda
Fleming, Sarah
Fthenou, Eleni
Granum, Berit and
Gutzkow, Kristine B.
Hardie, Laura J.
Knudsen, Lisbeth E. and
Kyrtopoulos, Soterios A.
Mendez, Michelle A.
Merlo, Domenico F.
and Nielsen, Jeanette K.
Rydberg, Per
Segerback, Dan
Sunyer,
Jordi
Wright, John
Tornqvist, Margareta
Kleinjans, Jos C.
and Kogevinas, Manolis
NewGeneris Consortium
