Περίληψη:
BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of
colorectal cancer (CRC), but little is known on the effect of
polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase
(ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of
CRC in Caucasian populations.
SUBJECTS/METHODS: A nested case-control study (1269 cases matched to
2107controls by sex, age, study centre and date of blood collection) was
conducted within the European Prospective Investigation into Cancer and
Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496
(ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type
variant of each polymorphism as reference category, CRC risk estimates
were calculated using conditional logistic regression, with adjustment
for matching factors.
RESULTS: Individuals carrying one copy of the rs1229984(A) (ADH1B)
allele (fast metabolizers) showed an average daily alcohol intake of 4.3
g per day lower than subjects with two copies of the rs1229984(G) allele
(slow metabolizers) (P-diff<0.01). None of the polymorphisms was
associated with risk of CRC or cancers of the colon or rectum. Heavy
alcohol intake was more strongly associated with CRC risk among carriers
of the rs1573496(C) allele, with odds ratio equal to 2.13 (95%
confidence interval: 1.26-3.59) compared with wild-type subjects with
low alcohol consumption P-((interaction)=0.07).
CONCLUSIONS: The rs1229984(A) (ADH1B) allele was associated with a
reduction in alcohol consumption. The rs1229984 (ADH1B), rs1573496
(ADH7) and rs441 (ALDH2) polymorphisms were not associated with CRC risk
overall in Western-European populations. However, the relationship
between alcohol and CRC risk might be modulated by the rs1573496 (ADH7)
polymorphism. European Journal of Clinical Nutrition (2012) 66,
1303-1308; doi: 10.1038/ejcn.2012.173; published online 14 November 2012
Συγγραφείς:
Ferrari, P.
McKay, J. D.
Jenab, M.
Brennan, P.
Canzian,
F.
Vogel, U.
Tjonneland, A.
Overvad, K.
Tolstrup, J. S.
and Boutron-Ruault, M-C
Clavel-Chapelon, F.
Morois, S. and
Kaaks, R.
Boeing, H.
Bergmann, M.
Trichopoulou, A. and
Katsoulis, M.
Trichopoulos, D.
Krogh, V.
Panico, S. and
Sacerdote, C.
Palli, D.
Tumino, R.
Peeters, P. H.
van
Gils, C. H.
Bueno-de-Mesquita, B.
Vrieling, A.
Lund, E. and
Hjartaker, A.
Agudo, A.
Suarez, L. R.
Arriola, L. and
Chirlaque, M-D
Ardanaz, E.
Sanchez, M-J
Manjer, J. and
Lindkvist, B.
Hallmans, G.
Palmqvist, R.
Allen, N.
Key,
T.
Khaw, K-T
Slimani, N.
Rinaldi, S.
Romieu, I. and
Boffetta, P.
Romaguera, D.
Norat, T.
Riboli, E.
