Τίτλος:
Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue:
Implications for Radiation Proctitis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background. Inflammation mediators related to radiation proctitis are
partially elucidated, and neovascularization is thought to play a key
role. Objectives. To investigate the expression of vascular endothelial
growth factor (VEGF) and CD31 as angiogenetic markers in postradiation
rectal tissue. Methods. Rectal mucosa biopsies from 11 patients who
underwent irradiation for prostate cancer were examined
immunohistochemically for the expression of VEGF and CD31 at three time
settings-before, at the completion of, and 6 months after radiotherapy.
VEGF expressing vascular endothelial cells and CD31 expressing
microvessels were counted separately in 10 high-power fields (HPFs).
VEGF vascular index (VEGF-VI) and microvascular density (MVD) were
calculated as the mean number of VEGF positive cells per vessel or the
mean number of vessels per HPF, respectively. Histological features were
also evaluated. Results. VEGF-VI was significantly higher at the
completion of radiotherapy (0.17 +/- 0.15 versus 0.41 +/- 0.24, P =
0.001) declining 6 months after. MVD increased significantly only 6
months after radiotherapy (7.3 +/- 3.2 versus 10.5 +/- 3.1, P < 0.005).
The histopathological examination revealed inflammatory changes at the
completion of radiotherapy regressing in the majority of cases 6 months
after. Conclusions. Our results showed that in postradiation rectal
biopsy specimens neoangiogenesis seems to be inflammation-related and
constitutes a significant postradiation component of the tissue injury.
Συγγραφείς:
Karamanolis, G.
Delladetsima, I.
Kouloulias, V.
Papaxoinis,
K.
Panayiotides, I.
Haldeopoulos, D.
Triantafyllou, K. and
Kelekis, N.
Ladas, S. D.
Περιοδικό:
Mediators of Inflammation
