Τίτλος:
Increased Expression of VEGF, COX-2, and Ki-67 in Barrett's Esophagus:
Does the Length Matter?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Barrett’s esophagus (BE) is a major complication of gastroesophageal
reflux disease due to its neoplastic potential. The length of the
metaplastic epithelium has been associated with cancer risk.
Angiogenesis, inflammation, and increased cell proliferation are early
events in the malignant sequence. Vascular endothelial growth factor
(VEGF), cyclooxygenase-2 (COX-2) and Ki-67 are indirect markers of these
complex mechanisms.
To examine the expression of VEGF, COX-2 and Ki-67 in BE and investigate
whether there is an association to Barrett’s length.
Immunohistochemistry for VEGF, COX-2, and Ki-67 was performed in
well-characterized Barrett’s samples, evaluated using a qualitative
scale and compared between long (LSBE) and short (SSBE) segments.
The study population consisted of 98 patients (78 men). LSBE and SSBE
was diagnosed in 33 (33.7%) and 65 (66.3%) cases, respectively. VEGF
was expressed in vascular endothelium of all Barrett’s specimens. COX-2
and Ki-67 expression in metaplastic epithelia was strong in 81.6 and
61.2% of the samples, respectively. Ki-67 expression was significantly
stronger in LSBE (p = 0.035), whereas VEGF expression was significantly
increased in SSBE (p = 0.031). COX-2 expression was not associated with
Barrett’s length.
VEGF, COX-2, and Ki-67 were overexpressed in the majority of Barrett’s
samples. The length was inversely associated with VEGF expression and
directly associated with Ki-67 expression.
Συγγραφείς:
Zampeli, Evanthia
Karamanolis, George
Morfopoulos, George and
Xirouchakis, Elias
Kalampoki, Vasiliki
Michopoulos, Spyros and
Savva, Sotiria
Tzias, Vasilios
Zouboulis-Vafiadis, Irene and
Kamberoglou, Dimitrios
Ladas, Spiros D.
Περιοδικό:
Digestive Diseases and Sciences
Λέξεις-κλειδιά:
Barrett’s esophagus; Length; VEGF; COX-2; Ki-67
DOI:
10.1007/s10620-011-1990-6
