Περίληψη:
New data regarding a positive association between smoking and risk of
epithelial ovarian cancer (EOC), especially the mucinous tumor type, has
started to emerge. The purpose of this study was to examine the
association between different measures of smoking exposures and subtypes
of EOC in a large cohort of women from 10 European countries. The
European Prospective Investigation into Cancer and Nutrition (EPIC)
cohort is a multicenter prospective study initiated in 1992. The
questionnaires included data about dietary, lifestyle, and health
factors. Information about cigarette smoking was collected from
individuals in all participating countries. We used Cox proportional
hazard regression models to estimate hazard ratio (HR) of EOC overall
and serous, mucinous, and endometroid histological subtypes, with 95%
confidence intervals (CIs) associated with different measures of smoking
exposures adjusting for confounding variables. Altogether 836 incident
EOC cases were identified among 326,831 women. The tumors were
classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell,
and 238 unspecified. Compared with never smokers, current smokers had a
significantly increased risk for mucinous tumors [HR = 1.85 (95% CI
1.083.16)] and those smoking more than 10 cigarettes per day had a
doubling in risk [HR = 2.25(95% CI 1.264.03)] as did those who had
smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI
1.074.43)]. The results from the EPIC study add further evidence that
smoking increases risk of mucinous ovarian cancer and support the notion
that the effect of smoking varies according to histological subtype.
Συγγραφείς:
Gram, Inger T.
Lukanova, Annekatrin
Brill, Ilene
Braaten,
Tonje
Lund, Eiliv
Lundin, Eva
Overvad, Kim
Tjonneland,
Anne
Clavel-Chapelon, Francoise
Chabbert-Buffet, Nathalie and
Bamia, Christina
Trichopoulou, Antonia
Zylis, Dimosthenis and
Masala, Giovanna
Berrino, Franco
Galasso, Rocco
Tumino,
Rosario
Sacerdote, Carlotta
Gavrilyuk, Oxana
Kristiansen,
Steinar
Rodriguez, Laudina
Bonet, Catalina
Maria Huerta,
Jose
Barricarte, Aurelio
Sanchez, Maria-Jose
Dorronsoro,
Miren
Jirstrom, Karin
Almquist, Martin
Idahl, Annika and
Bueno-de-Mesquita, H. Bas
Braem, Marie
Onland-Moret, Charlotte
and Tsilidis, Konstantinos K.
Allen, Naomi E.
Fedirko, Veronika
and Riboli, E.
Kaaks, Rudolf
