Περίληψη:
Objective In type 2 diabetes, although the impairment of postprandial
muscle blood flow response is well established, information on the
effect of this impairment on glucose uptake and lipid metabolism is
controversial. Design Postprandial forearm blood flow responses and
metabolic parameters were assessed in a cross-sectional study of
subjects at various stages of insulin resistance. Patients Eleven
healthy subjects (CONTROLS), 11 first-degree relatives of type-2
diabetics (RELATIVES), 10 patients with impaired glucose tolerance
(IGT), 10 diabetic patients with postprandial hyperglycaemia (DMA), and
13 diabetic patients with both fasting and postprandial hyperglycaemia
(DMB). Measurements All subjects received a meal. Blood was drawn from a
forearm deep vein and the radial artery at specific time-points during a
period of 360 min for measurements of glucose, insulin, triglycerides
and nonesterified-fatty acids. Forearm muscle blood flow was measured
with strain-gauge plethysmography. Glucose uptake and ISI Index were
calculated. Results Peak-baseline muscle blood flow was higher in
CONTROLS (3.32 +/- 0.4) than in RELATIVES (0.53 +/- 0.29), IGT (0.82 +/-
0.2), DMA (1.44 +/- 0.34), DMB (1.23 +/- 0.35 ml/min/100 ml tissue), P <
0.001. Glucose uptake (AUC0-360,mu mol/100 ml tissue) was higher in
CONTROLS (1023 +/- 132) than in RELATIVES (488 +/- 42), IGT (458 +/-
43), DMA (347 +/- 63), DMB (543 +/- 53), P < 0.001. ISI index,
postprandial triglycerides and nonesterified-fatty acids behaved in a
similar way. Peak-baseline muscle blood flow correlated positively with
glucose uptake (r = 0.440, P = 0.001) and ISI index (r = 0.397, P =
0.003), and negatively with postprandial triglycerides (r = -0.434, P =
0.001) and nonesterified-fatty acids (r = -0.370, P = 0.005).
Conclusions These results suggest that increase in muscle blood flow
after a meal is impaired at all stages of type-2 diabetes. This defect
influences glucose uptake and is associated with impaired lipid
metabolism in the postprandial state.
Συγγραφείς:
Lambadiari, Vaia
Mitrou, Panayota
Maratou, Eirini
Raptis,
Athanassios
Raptis, Sotirios A.
Dimitriadis, George
