Περίληψη:
Background: Earlier analyses within the EPIC study showed that dietary
fibre intake was inversely associated with colorectal cancer risk, but
results from some large cohort studies do not support this finding. We
explored whether the association remained after longer follow-up with a
near threefold increase in colorectal cancer cases, and if the
association varied by gender and tumour location.
Methodology/Principal Findings: After a mean follow-up of 11.0 years,
4,517 incident cases of colorectal cancer were documented. Total,
cereal, fruit, and vegetable fibre intakes were estimated from dietary
questionnaires at baseline. Hazard ratios (HRs) and 95% confidence
intervals (CIs) were estimated using Cox proportional hazards models
stratified by age, sex, and centre, and adjusted for total energy
intake, body mass index, physical activity, smoking, education,
menopausal status, hormone replacement therapy, oral contraceptive use,
and intakes of alcohol, folate, red and processed meats, and calcium.
After multivariable adjustments, total dietary fibre was inversely
associated with colorectal cancer (HR per 10 g/day increase in fibre
0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for
colon and rectal cancers. The association between total dietary fibre
and risk of colorectal cancer risk did not differ by age, sex, or
anthropometric, lifestyle, and dietary variables. Fibre from cereals and
fibre from fruit and vegetables were similarly associated with colon
cancer; but for rectal cancer, the inverse association was only evident
for fibre from cereals.
Conclusions/Significance: Our results strengthen the evidence for the
role of high dietary fibre intake in colorectal cancer prevention.
Συγγραφείς:
Murphy, Neil
Norat, Teresa
Ferrari, Pietro
Jenab, Mazda and
Bueno-de-Mesquita, Bas
Skeie, Guri
Dahm, Christina C. and
Overvad, Kim
Olsen, Anja
Tjonneland, Anne
Clavel-Chapelon,
Francoise
Boutron-Ruault, Marie Christine
Racine, Antoine and
Kaaks, Rudolf
Teucher, Birgit
Boeing, Heiner
Bergmann,
Manuela M.
Trichopoulou, Antonia
Trichopoulos, Dimitrios and
Lagiou, Pagona
Palli, Domenico
Pala, Valeria
Panico,
Salvatore
Tumino, Rosario
Vineis, Paolo
Siersema, Peter and
van Duijnhoven, Franzel
Peeters, Petra H. M.
Hjartaker, Anette
and Engeset, Dagrun
Gonzalez, Carlos A.
Sanchez, Maria-Jose and
Dorronsoro, Miren
Navarro, Carmen
Ardanaz, Eva
Quiros, Jose
R.
Sonestedt, Emily
Ericson, Ulrika
Nilsson, Lena and
Palmqvist, Richard
Khaw, Kay-Tee
Wareham, Nick
Key, Timothy
J.
Crowe, Francesca L.
Fedirko, Veronika
Wark, Petra A. and
Chuang, Shu-Chun
Riboli, Elio
