Περίληψη:
The aim of this study was to determine cardiovascular (CV) risk factors
(RFs) and target organ damage clustering in 21280 Greek hypertensives
stratified by gender and age. Glycemic and lipid profile were
determined, left ventricular mass index, estimated gromerular filtration
rate (eGFR), 10-years CV risk according to Framingham risk score (FRS)
and Heart-Score (HS) were calculated. Only 10.2% of patients had no
concomitant RFs, 53.1% had one (48.8% dyslipidemia, 3.4% smoking,
0.9% diabetes), 32.9% had two (26% dyslipidemia and smoking, 6.6%
dyslipidemia and diabetes, 0.3% smoking and diabetes) and 3.7% had all
four traditional RFs. Obesity was present in 30%, metabolic syndrome in
38%, low eGFR in 24% and left ventricular hypertrophy in 49%. Mean
FRS risk was 35% for males, 24.1% for females whereas in high risk
(>20%) were 68.7 and 50.7%, respectively (P<0.0001). Mean HS risk was
8.4% for males, 6.2% for females whereas in high risk (>5%) were 48.6
and 36.2%, respectively (P<0.0001). Age was correlated to pulse
pressure, eGFR, left ventricular mass index and CV risk (P<0.0001).
Ageing increased the risk difference between genders for total (P=0.001)
but not for fatal events (P=nonsignificant). In conclusion, as RFs
cluster in hypertensives, CV risk calculation should guide treatment
decisions. Journal of Human Hypertension (2012) 26, 443-451;
doi:10.1038/jhh.2011.55; published online 2 June 2011
Συγγραφείς:
Vyssoulis, G. P.
Karpanou, E. A.
Liakos, C. I.
Kyvelou, S-M
G.
Tzamou, V. E.
Michaelides, A. P.
Triantafyllou, A. I. and
Spanos, P. G.
Stefanadis, C. I.
