Περίληψη:
Background: In 2007 the World Cancer Research Fund (WCRF) and the
American Institute of Cancer Research (AICR) issued 8 recommendations
(plus 2 special recommendations) on diet, physical activity, and weight
management for cancer prevention on the basis of the most comprehensive
collection of available evidence.
Objective: We aimed to investigate whether concordance with the
WCRF/AICR recommendations was related to cancer risk in the European
Prospective Investigation into Cancer and Nutrition (EPIC) study.
Design: The present study included 386,355 EPIC participants from 9
European countries. At recruitment, dietary, anthropometric, and
lifestyle information was collected. A score was constructed based on
the WCRF/AICR recommendations on weight management, physical activity,
foods and drinks that promote weight gain, plant foods, animal foods,
alcoholic drinks, and breastfeeding for women; the score range was 0-6
for men and 0-7 for women. Higher scores indicated greater concordance
with WCRF/AICR recommendations. The association between the score and
cancer risk was estimated by using multivariable Cox regression models.
Results: Concordance with the score was significantly associated with
decreased risk of cancer. A 1-point increment in the score was
associated with a risk reduction of 5% (95% Cl: 3%, 7%) for total
cancer, 12% (95% CI: 9%, 16%) for colorectal cancer, and 16% (95%
CI: 9%, 22%) for stomach cancer. Significant associations were also
observed for cancers of the breast, endometrium, lung, kidney, upper
aerodigestive tract, liver, and esophagus but not for prostate, ovarian,
pancreatic, and bladder cancers.
Conclusion: Adherence to the WCRF/AICR recommendations for cancer
prevention may lower the risk of developing most types of cancer. Am J
Clin Nutr 2012;96:150-63.
Συγγραφείς:
Romaguera, Dora
Vergnaud, Anne-Claire
Peeters, Petra H.
van
Gils, Carla H.
Chan, Doris S. M.
Ferrari, Pietro
Romieu,
Isabelle
Jenab, Mazda
Slimani, Nadia
Clavel-Chapelon,
Francoise
Fagherazzi, Guy
Perquier, Florence
Kaaks, Rudolf
and Teucher, Birgit
Boeing, Heiner
von Ruesten, Anne and
Tjonneland, Anne
Olsen, Anja
Dahm, Christina C.
Overvad, Kim
and Ramon Quiros, Jose
Gonzalez, Carlos A.
Jose Sanchez, Maria
and Navarro, Carmen
Barricarte, Aurelio
Dorronsoro, Miren and
Khaw, Kay-Tee
Wareham, Nicholas J.
Crowe, Francesca L.
Key,
Timothy J.
Trichopoulou, Antonia
Lagiou, Pagona
Bamia,
Christina
Masala, Giovanna
Vineis, Paolo
Tumino, Rosario and
Sieri, Sabina
Panico, Salvatore
May, Anne M. and
Bueno-de-Mesquita, H. Bas
Buechner, Frederike L.
Wirfaelt,
Elisabet
Manjer, Jonas
Johansson, Ingegerd
Hallmans, Goeran
and Skeie, Guri
Benjaminsen Borch, Kristin
Parr, Christine L.
and Riboli, Elio
Norat, Teresa
