Περίληψη:
Purpose: Alcohol intake may adversely affect the concentrations of
endogenous sex hormones, and thus increase the risk of endometrial
cancer. However, epidemiologic studies have provided conflicting
results. Therefore, we investigated the association between alcohol
intake and endometrial cancer risk a large, multicenter, prospective
study.
Methods: From 1992 through 2010, 301,051 women in the European
Prospective Investigation into Cancer and Nutrition (EPIC) cohort were
followed for incident endometrial cancer (n = 1382). Baseline alcohol
consumption was assessed by country-specific, validated dietary
questionnaires. Information on past alcohol consumption was collected by
lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence
intervals (CIs) were estimated from Cox proportional hazard models.
Results: The multivariable HRs (and 95% CIs) compared with light
drinkers (0.1-6 g/d) were 1.03(0.88-1.20) for 0 g of alcohol per day at
baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24
g/d, 1.07(0.87-1.38) for 241-36 g/d, and 0.85(0.61-1.18) for more than
36 g/d (p(trend) = 0.77). No association was observed among former
drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers).
Null associations were also found between alcohol consumption at age 20
years, lifetime pattern of alcohol drinking, and baseline alcohol intake
from specific alcoholic beverages and endometrial cancer risk.
Conclusions: Our findings suggest no association between alcohol intake
and endometrial cancer risk. (c) 2013 Elsevier Inc. All rights reserved.
Συγγραφείς:
Fedirko, Veronika
Jenab, Mazda
Rinaldi, Sabina
Biessy,
Carine
Allen, Naomi E.
Dossus, Laure
Onland-Moret, N.
Charlotte
Schuetze, Madlen
Tjonneland, Anne
Hansen, Louise
and Overvad, Kim
Clavel-Chapelon, Francoise
Chabbert-Buffet,
Nathalie
Kaaks, Rudolf
Lukanova, Annekatrin
Bergmann,
Manuela M.
Boeing, Heiner
Trichopoulou, Antonia
Oustoglou,
Erifili
Barbitsioti, Antonia
Saieva, Calogero
Tagliabue,
Giovanna
Galasso, Rocco
Tumino, Rosario
Sacerdote, Carlotta
and Peeters, Petra H.
Bueno-de-Mesquita, H. Bas
Weiderpass,
Elisabete
Gram, Inger Torhild
Sanchez, Soledad
Duell, Eric
J.
Molina-Montes, Esther
Arriola, Larraitz
Chirlaque,
Maria-Dolores
Ardanaz, Eva
Manjer, Jonas
Lundin, Eva and
Idahl, Annika
Khaw, Kay-Tee
Romaguera-Bosch, Dora
Wark,
Petra A.
Norat, Teresa
Romieu, Isabelle
