Περίληψη:
The type and quantity of dietary carbohydrate as quantified by glycemic
index (GI) and glycemic load (GL), and dietary fiber may influence the
risk of liver and biliary tract cancers, but convincing evidence is
lacking.
The association between dietary GI/GL and carbohydrate intake with
hepatocellular carcinoma (HCC; N = 191), intrahepatic bile duct (IBD; N
= 66), and biliary tract (N = 236) cancer risk was investigated in 477
206 participants of the European Prospective Investigation into Cancer
and Nutrition cohort. Dietary intake was assessed by country-specific,
validated dietary questionnaires. Hazard ratios and 95% confidence
intervals were estimated from proportional hazard models. HBV/HCV status
was measured in a nested case-control subset.
Higher dietary GI, GL, or increased intake of total carbohydrate was not
associated with liver or biliary tract cancer risk. For HCC, divergent
risk estimates were observed for total sugar = 1.43 (1.17-1.74) per 50
g/day, total starch = 0.70 (0.55-0.90) per 50 g/day, and total dietary
fiber = 0.70 (0.52-0.93) per 10 g/day. The findings for dietary fiber
were confirmed among HBV/HCV-free participants [0.48 (0.23-1.01)].
Similar associations were observed for IBD [dietary fiber = 0.59
(0.37-0.99) per 10 g/day], but not biliary tract cancer.
Findings suggest that higher consumption of dietary fiber and lower
consumption of total sugars are associated with lower HCC risk. In
addition, high dietary fiber intake could be associated with lower IBD
cancer risk.
Συγγραφείς:
Fedirko, V.
Lukanova, A.
Bamia, C.
Trichopolou, A. and
Trepo, E.
Noethlings, U.
Schlesinger, S.
Aleksandrova, K.
and Boffetta, P.
Tjonneland, A.
Johnsen, N. F.
Overvad, K.
and Fagherazzi, G.
Racine, A.
Boutron-Ruault, M. C.
Grote,
V.
Kaaks, R.
Boeing, H.
Naska, A.
Adarakis, G. and
Valanou, E.
Palli, D.
Sieri, S.
Tumino, R.
Vineis, P.
and Panico, S.
Bueno-de-Mesquita, H. B(as).
Siersema, P. D. and
Peeters, P. H.
Weiderpass, E.
Skeie, G.
Engeset, D. and
Quiros, J. R.
Zamora-Ros, R.
Sanchez, M. J.
Amiano, P. and
Huerta, J. M.
Barricarte, A.
Johansen, D.
Lindkvist, B. and
Sund, M.
Werner, M.
Crowe, F.
Khaw, K. T.
Ferrari, P.
and Romieu, I.
Chuang, S. C.
Riboli, E.
Jenab, M.
