Περίληψη:
Studies assessing the effects of vitamin D or calcium intake on breast
cancer risk have been inconclusive. Furthermore, few studies have
evaluated them jointly. This study is the largest so far examining the
association of dietary vitamin D and calcium intake with breast cancer
risk in the European Prospective Investigation into Cancer and
Nutrition. During a mean follow-up of 8.8yr, 7760 incident invasive
breast cancer cases were identified among 319,985 women. Multivariable
Cox proportional hazards regression was used to estimate hazard ratios
(HR) and 95% confidence intervals (CI) for pre- and postmenopausal
breast cancer risk. Comparing the highest with the lowest quintile of
vitamin D intake, HR and 95% CI were 1.07 (0.871.32) and 1.02
(0.901.16) for pre- and postmenopausal women, respectively. The
corresponding HR and 95% CIs for calcium intake were 0.98 (0.801.19)
and 0.90 (0.791.02), respectively. For calcium intake in postmenopausal
women, the test for trend was borderline statistically significant
(Ptrend = 0.05). There was no significant interaction between vitamin D
and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-
and postmenopausal women, respectively). In this large prospective
cohort, we found no evidence for an association between dietary vitamin
D or calcium intake and breast cancer risk.
Συγγραφείς:
Abbas, Sascha
Linseisen, Jakob
Rohrmann, Sabine and
Chang-Claude, Jenny
Peeters, Petra H.
Engel, Pierre
Brustad,
Magritt
Lund, Eiliv
Skeie, Guri
Olsen, Anja
Tjonneland,
Anne
Overvad, Kim
Boutron-Ruault, Marie-Christine and
Clavel-Chapelon, Francoise
Fagherazzi, Guy
Kaaks, Rudolf and
Boeing, Heiner
Buijsse, Brian
Adarakis, George
Ouranos,
Vassilis
Trichopoulou, Antonia
Masala, Giovanna
Krogh,
Vittorio
Mattiello, Amalia
Tumino, Rosario
Sacerdote,
Carlotta
Buckland, Genevieve
Argueelles Suarez, Marcial Vicente
and Sanchez, Maria-Jose
Chirlaque, Maria-Dolores
Barricarte,
Aurelio
Amiano, Pilar
Manjer, Jonas
Wirfalt, Elisabet and
Lenner, Per
Sund, Malin
Bueno-de-Mesquita, H. B.
van
Duijnhoven, Franzel J. B.
Khaw, Kay-Tee
Wareham, Nick
Key,
Timothy J.
Fedirko, Veronika
Romieu, Isabelle
Gallo,
Valentina
Norat, Teresa
Wark, Petra A.
Riboli, Elio
