Περίληψη:
Background: Obesity has been linked to many adverse health consequences,
including breast cancer. This study aims to determine adipocytokine and
other biological changes in recently diagnosed breast cancer patients
before therapy is started.
Methods: A total of 109 female Saudi subjects [56 newly diagnosed,
treatment-naive, histologically-confirmed breast cancer cases and 53
age- and BMI-matched controls] were enrolled in this study.
Anthropometric data were collected. Serum insulin, adipocytokines and
plasminogen activator inhibitor-1 (PAI-1) concentrations were measured
using a customized multiplex Luminex assay. Hypersensitive C-Reactive
Protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and angiotensin
II (ANG II) were measured using ELISA.
Results: A few days in the diagnosis, breast cancer subjects had
significantly higher systolic blood pressure (p = 0.03), glucose (p =
0.01), triglycerides (p = 0.001), leptin (p = 0.044), resistin (p =
0.04), ANG II (p = 0.02), TNF-alpha (p = 0.045), and CRP (p = 0.04) than
the controls. On the other hand, HDL (p = 0.01) and adiponectin (p =
0.02) were significantly lower in cancer subjects than controls. A
significant association was found between elevated triglycerides (TG)
and breast cancer [OR (95% CI), 6.1(1.8, 15.6), p = 0.004], as well
as elevated ANG II [OR (95% CI), 5.2(1.2, 14.3), p = 0.03]. On the
other hand, aPAI and HDL correlated negatively with breast cancer [OR
(95% CI), 0.076(0.01, 0.34), p = 0.001; 0.30(0.09, 0.95), p 0.04,
respectively].
Conclusion: Circulating ANGII and triglycerides were positively
associated with early breast cancer. In contrast, HDL-cholesterol
correlated negatively with ANG II and aPAI in these patients. This
suggests that patients with recently diagnosed breast cancer have
biochemical changes consistent with an activated stress response and/or
that patients with metabolic syndrome manifestations have a higher risk
of developing this disease.
Συγγραφείς:
Alokail, Majed S.
Al-Daghri, Nasser
Abdulkareem, Amal
Draz,
Hossam M.
Yakout, Sobhy M.
Alnaami, Abdullah M.
Sabico,
Shaun
Alenad, Amal M.
Chrousos, George P.
