Τίτλος:
Allergy and risk of acute lymphoblastic leukemia among children: A
nationwide case control study in Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Several reports point to inverse associations between
allergies and ALL; yet, no study has explored this link using both
self-reported-data on allergic history and biomarkers of atopic
sensitization. Methods: Clinical information for the variables of
interest was available for 252 out of 292 cases of childhood (0-14
years) ALL, newly diagnosed across Greece over a 4.5 year period as well
as for 294 hospital controls. Allergen-specific-IgEs, as markers of
allergic predisposition, against 24 most prevalent respiratory and food
allergens, were determined, using an enzyme immunoassay procedure for
199 children with ALL and 113 controls. Cases were compared with
controls through frequency distributions and unconditional multiple
logistic regression models to estimate odds ratios (ORs) and 95%
confidence-intervals (CIs) regarding associations of allergy with
childhood ALL. Results: Self-reported-allergic history overall (OR:
0.49, 95%CI: 0.34-0.72) and practically each one of its main components
(respiratory, food, any other clinical allergy) were strongly and
inversely associated with ALL. Likewise, the serum IgE inverse
association was of the same magnitude (OR: 0.43, 95%CI: 0.22-0.84)
mainly contributed by food IgE (OR: 0.39, 95%CI: 0.18-0.83).
Conclusion: Beyond the already established inverse association of
allergic history with childhood ALL, a same magnitude association is
evident when serologic markers of allergic predisposition are used as an
alternative measure of allergy. Further research with more appropriate
study designs is needed to better understand possible associations
between prior allergy and childhood ALL risk. (c) 2012 Elsevier Ltd. All
rights reserved.
Συγγραφείς:
Lariou, Maria-Stella
Dikalioti, Stavroula K.
Dessypris, Nick and
Baka, Margarita
Polychronopoulou, Sophia and
Athanasiadou-Piperopoulou, Fani
Kalmanti, Maria
Fragandrea,
Ioanna
Moschovi, Maria
Germenis, Anastasios E.
Petridou,
Eleni T.
Περιοδικό:
Cancer Epidemiology and Prevention Biomarkers
Εκδότης:
Elsevier Sci Ltd, Exeter, United Kingdom
Λέξεις-κλειδιά:
Allergy; Childhood; Food and respiratory allergens; IgE; Leukemia
DOI:
10.1016/j.canep.2012.10.012
